TY - JOUR
T1 - Effects of the phthalate exposure during three gestation periods on birth weight and their gender differences
T2 - A birth cohort study in China
AU - Zhang, Yun wei
AU - Gao, Hui
AU - Mao, Lei jing
AU - Tao, Xing yong
AU - Ge, Xing
AU - Huang, Kun
AU - Zhu, Peng
AU - Hao, Jia hu
AU - Wang, Qu nan
AU - Xu, Yuan yuan
AU - Jin, Zhong xiu
AU - Sheng, Jie
AU - Xu, Ye qing
AU - Yan, Shuang qin
AU - Tao, Xu guang
AU - Tao, Fang biao
N1 - Funding Information:
We appreciate the sample detection support from the Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei (230032), China. We are also grateful for the approval for the questionnaire investigation and sample collection by Ma'anshan Women and Child Health Care Hospital, No. 72 Jiashan Road, Ma'anshan (243011), Anhui, China.
Publisher Copyright:
© 2017
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Phthalate has been widely used as a type of plasticiser in various consuming products in daily life. Recent studies have suggested that prenatal phthalate exposure may have adverse effects on fetal development. We aimed to identify the effects of in utero phthalate exposure on birth weight (BW). We evaluated a birth cohort comprising 3474 pregnant women and their single infants; 3103, 2975 and 2838 urine samples were collected in the first, second and third trimesters, respectively. Phthalate metabolites included monomethyl phthalate (MMP), monoethyl phthalate (MEP), mono-n-butyl phthalate (MBP), monobenzyl phthalate (MBzP), mono-(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEHHP), and mono-(2-ethyl-5-hydroxylhexyl) phthalate (MEOHP), which were analysed in the urine by using high performance liquid chromatography–tandem mass spectrometry. Mixed linear model was used in the statistical analysis. Generally, MMP and MEP exposure during pregnancy was associated with decreased birth weight of infants (MMP, β = − 12.192, p = 0.009; MEP, β = − 11.876, p = 0.014). Hierarchical analysis found that MMP and MEOHP exposure was associated with decreased infants' birth weight only in low birth weight groups (MMP, β = − 42.538, p = 0.005; MEOHP, β = − 63.224, p = 0.008); MEHP and MEHHP exposure was associated with decreased infants' birth weight in both low birth weight group (MEHP, β = − 42.348, p = 0.035; MEHHP, β = − 50.485, p = 0.006) and high birth weight group (MEHP, β = − 16.580, p = 0.034; MEHHP, β = − 18.009, p = 0.040), MBP and MEHP exposure were associated with increased infants' birth weight in male NBW group (MBP, β = 10.438, p = 0.039; MEHP, β = 13.223, p = 0.017). Moreover, the effect has sex difference. The reduction of birth weight associated with MEHP and MEOHP exposure was stronger in male infants, while MMP and MEP exposure was more significant in female infants.
AB - Phthalate has been widely used as a type of plasticiser in various consuming products in daily life. Recent studies have suggested that prenatal phthalate exposure may have adverse effects on fetal development. We aimed to identify the effects of in utero phthalate exposure on birth weight (BW). We evaluated a birth cohort comprising 3474 pregnant women and their single infants; 3103, 2975 and 2838 urine samples were collected in the first, second and third trimesters, respectively. Phthalate metabolites included monomethyl phthalate (MMP), monoethyl phthalate (MEP), mono-n-butyl phthalate (MBP), monobenzyl phthalate (MBzP), mono-(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEHHP), and mono-(2-ethyl-5-hydroxylhexyl) phthalate (MEOHP), which were analysed in the urine by using high performance liquid chromatography–tandem mass spectrometry. Mixed linear model was used in the statistical analysis. Generally, MMP and MEP exposure during pregnancy was associated with decreased birth weight of infants (MMP, β = − 12.192, p = 0.009; MEP, β = − 11.876, p = 0.014). Hierarchical analysis found that MMP and MEOHP exposure was associated with decreased infants' birth weight only in low birth weight groups (MMP, β = − 42.538, p = 0.005; MEOHP, β = − 63.224, p = 0.008); MEHP and MEHHP exposure was associated with decreased infants' birth weight in both low birth weight group (MEHP, β = − 42.348, p = 0.035; MEHHP, β = − 50.485, p = 0.006) and high birth weight group (MEHP, β = − 16.580, p = 0.034; MEHHP, β = − 18.009, p = 0.040), MBP and MEHP exposure were associated with increased infants' birth weight in male NBW group (MBP, β = 10.438, p = 0.039; MEHP, β = 13.223, p = 0.017). Moreover, the effect has sex difference. The reduction of birth weight associated with MEHP and MEOHP exposure was stronger in male infants, while MMP and MEP exposure was more significant in female infants.
KW - Birth weight
KW - Phthalate esters
KW - Prenatal exposure
KW - Sex characteristics
KW - Urinary metabolites
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UR - http://www.scopus.com/inward/citedby.url?scp=85028710400&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2017.08.319
DO - 10.1016/j.scitotenv.2017.08.319
M3 - Article
C2 - 28886917
AN - SCOPUS:85028710400
SN - 0048-9697
VL - 613-614
SP - 1573
EP - 1578
JO - Science of the Total Environment
JF - Science of the Total Environment
ER -