Effects of the hematoregulatory peptide SKandF 107647 alone and in combination with amphotericin B against disseminated candidiasis in persistently neutropenic rabbits

Caron A. Lyman, Corina Gonzalez, Mark Schneider, James Lee, Thomas J. Walsh

Research output: Contribution to journalArticle

Abstract

The effects of the hematoregulatory peptide SKandF 107647 were examined in a persistently and profoundly neutropenic rabbit model of disseminated candidiasis in order to determine its potential to enhance resistance against infection and its role as an adjunct to conventional antifungal chemotherapy. In healthy animals, SKandF 107647 elicited a time-dependent increase in CD11b-positive monocytes and neutrophils. When administered to neutropenic rabbits infected with Candida albicans, no significant differences in the number of CFU per gram in any of the tissues tested compared with the number in untreated control rabbits were detected. However, when SKandF 107647 was administered in combination with low doses of amphotericin B, there was a significant reduction in organism burden in the lungs, liver, spleen, and kidneys compared with the burdens in the organs of untreated control animals and in the lungs and kidneys compared with the burdens in the lungs and kidneys of animals treated with amphotericin B alone. These data suggest a potential role for this peptide as adjunctive therapy in combination with conventional antifungal agents in the treatment of disseminated candidiasis in the setting of profound and persistent neutropenia.

Original languageEnglish (US)
Pages (from-to)2165-2169
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume43
Issue number9
StatePublished - Sep 1999
Externally publishedYes

Fingerprint

Candidiasis
Amphotericin B
Rabbits
Kidney
Lung
Peptides
Antifungal Agents
Neutropenia
Candida albicans
Monocytes
Neutrophils
Spleen
Drug Therapy
Liver
Therapeutics
Infection

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Effects of the hematoregulatory peptide SKandF 107647 alone and in combination with amphotericin B against disseminated candidiasis in persistently neutropenic rabbits. / Lyman, Caron A.; Gonzalez, Corina; Schneider, Mark; Lee, James; Walsh, Thomas J.

In: Antimicrobial Agents and Chemotherapy, Vol. 43, No. 9, 09.1999, p. 2165-2169.

Research output: Contribution to journalArticle

@article{44888574762f4e7a986a277f9fb64bca,
title = "Effects of the hematoregulatory peptide SKandF 107647 alone and in combination with amphotericin B against disseminated candidiasis in persistently neutropenic rabbits",
abstract = "The effects of the hematoregulatory peptide SKandF 107647 were examined in a persistently and profoundly neutropenic rabbit model of disseminated candidiasis in order to determine its potential to enhance resistance against infection and its role as an adjunct to conventional antifungal chemotherapy. In healthy animals, SKandF 107647 elicited a time-dependent increase in CD11b-positive monocytes and neutrophils. When administered to neutropenic rabbits infected with Candida albicans, no significant differences in the number of CFU per gram in any of the tissues tested compared with the number in untreated control rabbits were detected. However, when SKandF 107647 was administered in combination with low doses of amphotericin B, there was a significant reduction in organism burden in the lungs, liver, spleen, and kidneys compared with the burdens in the organs of untreated control animals and in the lungs and kidneys compared with the burdens in the lungs and kidneys of animals treated with amphotericin B alone. These data suggest a potential role for this peptide as adjunctive therapy in combination with conventional antifungal agents in the treatment of disseminated candidiasis in the setting of profound and persistent neutropenia.",
author = "Lyman, {Caron A.} and Corina Gonzalez and Mark Schneider and James Lee and Walsh, {Thomas J.}",
year = "1999",
month = "9",
language = "English (US)",
volume = "43",
pages = "2165--2169",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "9",

}

TY - JOUR

T1 - Effects of the hematoregulatory peptide SKandF 107647 alone and in combination with amphotericin B against disseminated candidiasis in persistently neutropenic rabbits

AU - Lyman, Caron A.

AU - Gonzalez, Corina

AU - Schneider, Mark

AU - Lee, James

AU - Walsh, Thomas J.

PY - 1999/9

Y1 - 1999/9

N2 - The effects of the hematoregulatory peptide SKandF 107647 were examined in a persistently and profoundly neutropenic rabbit model of disseminated candidiasis in order to determine its potential to enhance resistance against infection and its role as an adjunct to conventional antifungal chemotherapy. In healthy animals, SKandF 107647 elicited a time-dependent increase in CD11b-positive monocytes and neutrophils. When administered to neutropenic rabbits infected with Candida albicans, no significant differences in the number of CFU per gram in any of the tissues tested compared with the number in untreated control rabbits were detected. However, when SKandF 107647 was administered in combination with low doses of amphotericin B, there was a significant reduction in organism burden in the lungs, liver, spleen, and kidneys compared with the burdens in the organs of untreated control animals and in the lungs and kidneys compared with the burdens in the lungs and kidneys of animals treated with amphotericin B alone. These data suggest a potential role for this peptide as adjunctive therapy in combination with conventional antifungal agents in the treatment of disseminated candidiasis in the setting of profound and persistent neutropenia.

AB - The effects of the hematoregulatory peptide SKandF 107647 were examined in a persistently and profoundly neutropenic rabbit model of disseminated candidiasis in order to determine its potential to enhance resistance against infection and its role as an adjunct to conventional antifungal chemotherapy. In healthy animals, SKandF 107647 elicited a time-dependent increase in CD11b-positive monocytes and neutrophils. When administered to neutropenic rabbits infected with Candida albicans, no significant differences in the number of CFU per gram in any of the tissues tested compared with the number in untreated control rabbits were detected. However, when SKandF 107647 was administered in combination with low doses of amphotericin B, there was a significant reduction in organism burden in the lungs, liver, spleen, and kidneys compared with the burdens in the organs of untreated control animals and in the lungs and kidneys compared with the burdens in the lungs and kidneys of animals treated with amphotericin B alone. These data suggest a potential role for this peptide as adjunctive therapy in combination with conventional antifungal agents in the treatment of disseminated candidiasis in the setting of profound and persistent neutropenia.

UR - http://www.scopus.com/inward/record.url?scp=0032850548&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032850548&partnerID=8YFLogxK

M3 - Article

VL - 43

SP - 2165

EP - 2169

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 9

ER -