Abstract
Abstract: Experiments were conducted to investigate the effects of the convulsant l‐methionine‐dl‐sulfoximine (MSO) on striatal dopamine (DA) metabolism. Intraventricular injections of MSO produced a transient increase in striatal DA release followed by inhibition of DA release for up to 3 days, which paralleled the inhibition by MSO of the enzyme glutamine synthetase (GS). DA synthesis was decreased for up to 24 h after injection of MSO, but returned to normal within 3 days after MSO administration. Intrastriatal injections of MSO produced a pronounced decrease in striatal DA release and inhibition of striatal GS activity 24 h postinjection but, unlike intraventricular MSO, did not produce behavioral convulsions. Glutamate‐DA interactions may be responsible for the observed effects.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 452-457 |
| Number of pages | 6 |
| Journal | Journal of Neurochemistry |
| Volume | 39 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 1982 |
| Externally published | Yes |
Keywords
- Convulsants
- Dopamine
- Glial cells
- Glutamate
- Glutamine synthetase
- Methionine sulfoximine
ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience