Effects of the Convulsant Methionine Sulfoximine on Striatal Dopamine Metabolism

Jeffrey D. Rothstein, Boris Tabakoff

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract: Experiments were conducted to investigate the effects of the convulsant l‐methionine‐dl‐sulfoximine (MSO) on striatal dopamine (DA) metabolism. Intraventricular injections of MSO produced a transient increase in striatal DA release followed by inhibition of DA release for up to 3 days, which paralleled the inhibition by MSO of the enzyme glutamine synthetase (GS). DA synthesis was decreased for up to 24 h after injection of MSO, but returned to normal within 3 days after MSO administration. Intrastriatal injections of MSO produced a pronounced decrease in striatal DA release and inhibition of striatal GS activity 24 h postinjection but, unlike intraventricular MSO, did not produce behavioral convulsions. Glutamate‐DA interactions may be responsible for the observed effects.

Original languageEnglish (US)
Pages (from-to)452-457
Number of pages6
JournalJournal of Neurochemistry
Volume39
Issue number2
DOIs
StatePublished - Aug 1982
Externally publishedYes

Keywords

  • Convulsants
  • Dopamine
  • Glial cells
  • Glutamate
  • Glutamine synthetase
  • Methionine sulfoximine

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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