Effects of the calcium channel blocker, verapamil, on asthmatic airway responses to muscarinic, histaminergic, and allergenic stimuli

J. E. Fish, Philip S. Norman

Research output: Contribution to journalArticle

Abstract

The effect of calcium channel blocking agents on bronchomotor tone and airway responsiveness to inhaled provocative stimuli remains controversial. In this study we examined the effects of verapamil (a papaverine derivative) on baseline airway function as well as the response to methacholine, histamine, and ragweed allergen. Verapamil was chosen because of its aqueous solubility and hence suitability for aerosol administration in higher doses than previously given. The effects of 5 mg and 12.5 mg aerosolized verapamil doses were compared with placebo as separate parts of the same study in subjects with ragweed-allergic asthma. Neither dose of verapamil was found to produce bronchodilatation within 30 min after aerosol administration. At the 12.5 mg dose, however, we observed mild to moderate bronchospasm occurring within 5 min of administration, with a return toward baseline within 30 to 40 min. This bronchoconstrictor effect was unrelated to the low osmolarity of the drug solution (33 mosmol/L). Responses to methacholine, histamine, and ragweed allergen were unaltered by drug pretreatment at the 5-mg dose. At the 12.5-mg dose, however, we found significant inhibition of methacholine responsiveness but not effect on histamine or allergen responses. From these studies we conclude that verapamil can influence airway function by modulating agonist-induced bronchoconstriction. The selectivity of this inhibitory effect on muscarcinic responses alone, however, leaves questionable the importance of this activity with regard to its clinical implications.

Original languageEnglish (US)
Pages (from-to)730-734
Number of pages5
JournalAmerican Review of Respiratory Disease
Volume133
Issue number5
StatePublished - 1986

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Calcium Channel Blockers
Verapamil
Cholinergic Agents
Ambrosia
Methacholine Chloride
Allergens
Histamine
Aerosols
Bronchoconstrictor Agents
Bronchial Spasm
Papaverine
Bronchoconstriction
Calcium Channels
Pharmaceutical Preparations
Osmolar Concentration
Solubility
Asthma
Placebos

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

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title = "Effects of the calcium channel blocker, verapamil, on asthmatic airway responses to muscarinic, histaminergic, and allergenic stimuli",
abstract = "The effect of calcium channel blocking agents on bronchomotor tone and airway responsiveness to inhaled provocative stimuli remains controversial. In this study we examined the effects of verapamil (a papaverine derivative) on baseline airway function as well as the response to methacholine, histamine, and ragweed allergen. Verapamil was chosen because of its aqueous solubility and hence suitability for aerosol administration in higher doses than previously given. The effects of 5 mg and 12.5 mg aerosolized verapamil doses were compared with placebo as separate parts of the same study in subjects with ragweed-allergic asthma. Neither dose of verapamil was found to produce bronchodilatation within 30 min after aerosol administration. At the 12.5 mg dose, however, we observed mild to moderate bronchospasm occurring within 5 min of administration, with a return toward baseline within 30 to 40 min. This bronchoconstrictor effect was unrelated to the low osmolarity of the drug solution (33 mosmol/L). Responses to methacholine, histamine, and ragweed allergen were unaltered by drug pretreatment at the 5-mg dose. At the 12.5-mg dose, however, we found significant inhibition of methacholine responsiveness but not effect on histamine or allergen responses. From these studies we conclude that verapamil can influence airway function by modulating agonist-induced bronchoconstriction. The selectivity of this inhibitory effect on muscarcinic responses alone, however, leaves questionable the importance of this activity with regard to its clinical implications.",
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T1 - Effects of the calcium channel blocker, verapamil, on asthmatic airway responses to muscarinic, histaminergic, and allergenic stimuli

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AU - Norman, Philip S.

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