Effects of the benzodiazepine GABAA α1-preferring ligand, 3-propoxy-β-carboline hydrochloride (3-PBC), on alcohol seeking and self-administration in baboons

Barbara J. Kaminski, Michael L. Van Linn, James M. Cook, Wenyuan Yin, Elise Weerts

Research output: Contribution to journalArticle

Abstract

Rationale: The various α subtypes of GABAA receptors have been strongly implicated in alcohol reinforcement and consumption. Objectives: The effects of the GABAA α1-preferring ligand, 3-propoxy-β-carboline hydrochloride (3-PBC), on seeking and self-administration responses were evaluated in two groups of baboons trained under a 3-component chained schedule of reinforcement (CSR). Methods: Alcohol (4 % w/v; n = 5; alcohol group) or a preferred nonalcoholic beverage (n = 4; control group) was available for self-administration only in component 3 of the CSR. Responses in component 2 provided indices of motivation to drink (seeking). 3-PBC (1.0-30.0 mg/kg) and saline were administered before drinking sessions under both acute and 5-day dosing conditions. Results: Repeated, and not acute, doses of 3-PBC significantly decreased total self-administration responses (p <0.05), volume consumed (p <0.05), and gram per kilogram of alcohol (p <0.05) in the alcohol group. In the control group, 5-day administration of 3-PBC significantly decreased total self-administration responses (p <0.05) but produced nonsignificant decreases in volume consumed. Within-session pattern of drinking was characterized by a high level of drinking in the first 20 min of the session for both groups, which was significantly (p <0.05) decreased by all doses of 3-PBC (1.0-18.0 mg/kg) only in the alcohol group. In contrast, the first drinking bout in the control group was only reduced at the highest doses of 3-PBC (10.0 and 18.0 mg/kg). Conclusions: The results support the involvement of the GABAA α1 subtype receptor in alcohol reinforcement and consumption.

Original languageEnglish (US)
Pages (from-to)127-136
Number of pages10
JournalPsychopharmacology
Volume227
Issue number1
DOIs
StatePublished - May 2013

Fingerprint

Carbolines
Self Administration
Papio
Benzodiazepines
Alcohols
Ligands
Drinking
Reinforcement Schedule
Alcohol Drinking
Control Groups
Beverages
GABA-A Receptors
Motivation

Keywords

  • 3-PBC
  • 3-Propoxy-β-carboline hydrochloride
  • Alcohol
  • Baboon
  • Self-administration

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Cite this

Effects of the benzodiazepine GABAA α1-preferring ligand, 3-propoxy-β-carboline hydrochloride (3-PBC), on alcohol seeking and self-administration in baboons. / Kaminski, Barbara J.; Van Linn, Michael L.; Cook, James M.; Yin, Wenyuan; Weerts, Elise.

In: Psychopharmacology, Vol. 227, No. 1, 05.2013, p. 127-136.

Research output: Contribution to journalArticle

@article{70bcc5e15986407d820c5a9a84ed9746,
title = "Effects of the benzodiazepine GABAA α1-preferring ligand, 3-propoxy-β-carboline hydrochloride (3-PBC), on alcohol seeking and self-administration in baboons",
abstract = "Rationale: The various α subtypes of GABAA receptors have been strongly implicated in alcohol reinforcement and consumption. Objectives: The effects of the GABAA α1-preferring ligand, 3-propoxy-β-carboline hydrochloride (3-PBC), on seeking and self-administration responses were evaluated in two groups of baboons trained under a 3-component chained schedule of reinforcement (CSR). Methods: Alcohol (4 {\%} w/v; n = 5; alcohol group) or a preferred nonalcoholic beverage (n = 4; control group) was available for self-administration only in component 3 of the CSR. Responses in component 2 provided indices of motivation to drink (seeking). 3-PBC (1.0-30.0 mg/kg) and saline were administered before drinking sessions under both acute and 5-day dosing conditions. Results: Repeated, and not acute, doses of 3-PBC significantly decreased total self-administration responses (p <0.05), volume consumed (p <0.05), and gram per kilogram of alcohol (p <0.05) in the alcohol group. In the control group, 5-day administration of 3-PBC significantly decreased total self-administration responses (p <0.05) but produced nonsignificant decreases in volume consumed. Within-session pattern of drinking was characterized by a high level of drinking in the first 20 min of the session for both groups, which was significantly (p <0.05) decreased by all doses of 3-PBC (1.0-18.0 mg/kg) only in the alcohol group. In contrast, the first drinking bout in the control group was only reduced at the highest doses of 3-PBC (10.0 and 18.0 mg/kg). Conclusions: The results support the involvement of the GABAA α1 subtype receptor in alcohol reinforcement and consumption.",
keywords = "3-PBC, 3-Propoxy-β-carboline hydrochloride, Alcohol, Baboon, Self-administration",
author = "Kaminski, {Barbara J.} and {Van Linn}, {Michael L.} and Cook, {James M.} and Wenyuan Yin and Elise Weerts",
year = "2013",
month = "5",
doi = "10.1007/s00213-012-2946-z",
language = "English (US)",
volume = "227",
pages = "127--136",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Effects of the benzodiazepine GABAA α1-preferring ligand, 3-propoxy-β-carboline hydrochloride (3-PBC), on alcohol seeking and self-administration in baboons

AU - Kaminski, Barbara J.

AU - Van Linn, Michael L.

AU - Cook, James M.

AU - Yin, Wenyuan

AU - Weerts, Elise

PY - 2013/5

Y1 - 2013/5

N2 - Rationale: The various α subtypes of GABAA receptors have been strongly implicated in alcohol reinforcement and consumption. Objectives: The effects of the GABAA α1-preferring ligand, 3-propoxy-β-carboline hydrochloride (3-PBC), on seeking and self-administration responses were evaluated in two groups of baboons trained under a 3-component chained schedule of reinforcement (CSR). Methods: Alcohol (4 % w/v; n = 5; alcohol group) or a preferred nonalcoholic beverage (n = 4; control group) was available for self-administration only in component 3 of the CSR. Responses in component 2 provided indices of motivation to drink (seeking). 3-PBC (1.0-30.0 mg/kg) and saline were administered before drinking sessions under both acute and 5-day dosing conditions. Results: Repeated, and not acute, doses of 3-PBC significantly decreased total self-administration responses (p <0.05), volume consumed (p <0.05), and gram per kilogram of alcohol (p <0.05) in the alcohol group. In the control group, 5-day administration of 3-PBC significantly decreased total self-administration responses (p <0.05) but produced nonsignificant decreases in volume consumed. Within-session pattern of drinking was characterized by a high level of drinking in the first 20 min of the session for both groups, which was significantly (p <0.05) decreased by all doses of 3-PBC (1.0-18.0 mg/kg) only in the alcohol group. In contrast, the first drinking bout in the control group was only reduced at the highest doses of 3-PBC (10.0 and 18.0 mg/kg). Conclusions: The results support the involvement of the GABAA α1 subtype receptor in alcohol reinforcement and consumption.

AB - Rationale: The various α subtypes of GABAA receptors have been strongly implicated in alcohol reinforcement and consumption. Objectives: The effects of the GABAA α1-preferring ligand, 3-propoxy-β-carboline hydrochloride (3-PBC), on seeking and self-administration responses were evaluated in two groups of baboons trained under a 3-component chained schedule of reinforcement (CSR). Methods: Alcohol (4 % w/v; n = 5; alcohol group) or a preferred nonalcoholic beverage (n = 4; control group) was available for self-administration only in component 3 of the CSR. Responses in component 2 provided indices of motivation to drink (seeking). 3-PBC (1.0-30.0 mg/kg) and saline were administered before drinking sessions under both acute and 5-day dosing conditions. Results: Repeated, and not acute, doses of 3-PBC significantly decreased total self-administration responses (p <0.05), volume consumed (p <0.05), and gram per kilogram of alcohol (p <0.05) in the alcohol group. In the control group, 5-day administration of 3-PBC significantly decreased total self-administration responses (p <0.05) but produced nonsignificant decreases in volume consumed. Within-session pattern of drinking was characterized by a high level of drinking in the first 20 min of the session for both groups, which was significantly (p <0.05) decreased by all doses of 3-PBC (1.0-18.0 mg/kg) only in the alcohol group. In contrast, the first drinking bout in the control group was only reduced at the highest doses of 3-PBC (10.0 and 18.0 mg/kg). Conclusions: The results support the involvement of the GABAA α1 subtype receptor in alcohol reinforcement and consumption.

KW - 3-PBC

KW - 3-Propoxy-β-carboline hydrochloride

KW - Alcohol

KW - Baboon

KW - Self-administration

UR - http://www.scopus.com/inward/record.url?scp=84876035790&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876035790&partnerID=8YFLogxK

U2 - 10.1007/s00213-012-2946-z

DO - 10.1007/s00213-012-2946-z

M3 - Article

C2 - 23271191

AN - SCOPUS:84876035790

VL - 227

SP - 127

EP - 136

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 1

ER -