Effects of thallium ion on cellular components of the skin

Jack L. Arbiser, Rhoda Alani, Evelyn Flynn, Virginia Wooten, Hugh Randolph Byers

Research output: Contribution to journalArticlepeer-review

Abstract

Thallium salts have been employed by dermatologists to cause depilation, and dermatologic features are prominent in thallium overdose. These features include alopecia and follicular hyperkeratosis. Administration of thallium to pregnant animals results in limb deformities, similar to those seen after thalidomide embryopathy. These findings suggest that thallium may act on keratinocytes, melanocytes, and endothelial cells. We show that thallium exerts pleiotropic effects on proliferation, cell shape and motility of multiple cell types. These findings may help explain the clinical findings of thallotoxicosis.

Original languageEnglish (US)
Pages (from-to)147-155
Number of pages9
JournalJournal of Dermatology
Volume24
Issue number3
DOIs
StatePublished - 1997
Externally publishedYes

Keywords

  • endothelium
  • keratinocytes
  • melanoma
  • thallium

ASJC Scopus subject areas

  • Dermatology

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