Effects of testosterone replacement on metabolic and inflammatory markers in men with opioid-induced androgen deficiency

Grace Huang, Thomas Travison, Marcello Maggio, Robert R. Edwards, Shehzad Basaria

Research output: Contribution to journalArticle

Abstract

Objective: Symptomatic androgen deficiency is common in patients taking opioid analgesics, and testosterone replacement in these men improves libido, quality of life and body composition. However, the effects of testosterone replacement on metabolic and inflammatory markers in this setting have not been evaluated. This is important as opiate use itself has been associated with metabolic abnormalities. The objective of this investigation was to determine the effects of testosterone administration on metabolic and inflammatory markers in adult men with opioid-induced androgen deficiency. Methods: Sixty-four nondiabetic men aged 18 to 64 years using opioid analgesics for chronic noncancer pain with total testosterone levels

Original languageEnglish (US)
Pages (from-to)232-238
Number of pages7
JournalClinical Endocrinology
Volume85
Issue number2
DOIs
StatePublished - Aug 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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