Abstract
Symptomatic androgen deficiency is common in patients taking opioid analgesics, as these drugs potently suppress the hypothalamic-pituitary-gonadal axis. However, the efficacy of testosterone replacement in this setting remains unclear. The objective of this trialwas to evaluate the efficacy of testosterone replacement on pain perception and other androgen-dependent outcomes inmen with opioid-induced androgen deficiency. We conducted a randomized, double-blind, parallel placebo-controlled trial at an outpatient academic research center. Participants were men aged 18 to 64 years on opioid analgesics for chronic noncancer pain, and total testosterone levels were
Original language | English (US) |
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Pages (from-to) | 280-288 |
Number of pages | 9 |
Journal | Pain |
Volume | 156 |
Issue number | 2 |
DOIs | |
State | Published - 2015 |
Externally published | Yes |
Keywords
- Low testosterone
- Opioid-induced androgen deficiency
- Pain perception
- Quality of life
- Sexual function
ASJC Scopus subject areas
- Clinical Neurology
- Anesthesiology and Pain Medicine
- Neurology
- Pharmacology