Effects of testosterone replacement in men with opioid-induced androgen deficiency: A randomized controlled trial

Shehzad Basaria, Thomas G. Travison, Daniel Alford, Philip E. Knapp, Kjersten Teeter, Christine Cahalan, Richard Eder, Kishore Lakshman, Eric Bachman, George Mensing, Marc O. Martel, Dillon Le, Helene Stroh, Shalender Bhasin, Ajay D. Wasan, Robert R. Edwards

Research output: Contribution to journalArticlepeer-review

Abstract

Symptomatic androgen deficiency is common in patients taking opioid analgesics, as these drugs potently suppress the hypothalamic-pituitary-gonadal axis. However, the efficacy of testosterone replacement in this setting remains unclear. The objective of this trialwas to evaluate the efficacy of testosterone replacement on pain perception and other androgen-dependent outcomes inmen with opioid-induced androgen deficiency. We conducted a randomized, double-blind, parallel placebo-controlled trial at an outpatient academic research center. Participants were men aged 18 to 64 years on opioid analgesics for chronic noncancer pain, and total testosterone levels were

Original languageEnglish (US)
Pages (from-to)280-288
Number of pages9
JournalPain
Volume156
Issue number2
DOIs
StatePublished - 2015
Externally publishedYes

Keywords

  • Low testosterone
  • Opioid-induced androgen deficiency
  • Pain perception
  • Quality of life
  • Sexual function

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine
  • Neurology
  • Pharmacology

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