TY - JOUR
T1 - Effects of testosterone administration on nocturnal cortisol secretion in healthy older men
AU - Muniyappa, Ranganath
AU - Veldhuis, Johannes D.
AU - Harman, S. Mitchell
AU - Sorkin, John D.
AU - Blackman, Marc R.
N1 - Funding Information:
Intramural Research Programs of the National Center for Complementary and Alternative Medicine to R.M., Bethesda, Maryland and the National Institute on Aging, Baltimore, Maryland; National Institutes of Health Research Grants RO-1 AG11005 to M.R.B. and DK073148 to J.D.V.; General Clinical Research Center Grant MO-1-RR-02719 to M.R.B. from the National Center for Research Resources, National Institutes of Health, Bethesda, Maryland; Department of Veterans Affairs and Veterans Affairs Medical Center Baltimore Geriatrics Research, Education and Clinical Center; Claude D. Pepper Older Americans Independence Center Grant P60-AG-12583 to J.D.S. at the University of Maryland; and the Research Service, Veterans Affairs Medical Center, Washington DC to M.R.B.
PY - 2010/11
Y1 - 2010/11
N2 - In animal studies, testosterone decreases, whereas estrogen increases, cortisol production. In one clinical study, short-term testosterone replacement attenuated corticotrophin-releasing hormone-stimulated cortisol secretion during leuprolide-induced hypogonadism in young men. The effects of longer term testosterone treatment on spontaneous cortisol secretion in younger or older men are unknown. In a randomized, double-masked placebo-controlled study, we assessed the effects of testosterone supplementation (100 mg intramuscular every 2 week) for 26 weeks on nocturnal cortisol secretory dynamics in healthy older men. Testosterone administration increased early morning serum concentrations of free testosterone by 34%, decreased sex hormone-binding globulin by 20%, and did not alter early morning concentrations of cortisol-binding globulin or cortisol compared with placebo treatment. Testosterone did not significantly alter nocturnal mean and integrated cortisol concentrations, cortisol burst frequency, mass/burst, basal secretion, pulsatile cortisol production rate, pattern regularity, or approximate entropy. We conclude that low-dose testosterone supplementation for 26 weeks does not affect spontaneous nocturnal cortisol secretion in healthy older men.
AB - In animal studies, testosterone decreases, whereas estrogen increases, cortisol production. In one clinical study, short-term testosterone replacement attenuated corticotrophin-releasing hormone-stimulated cortisol secretion during leuprolide-induced hypogonadism in young men. The effects of longer term testosterone treatment on spontaneous cortisol secretion in younger or older men are unknown. In a randomized, double-masked placebo-controlled study, we assessed the effects of testosterone supplementation (100 mg intramuscular every 2 week) for 26 weeks on nocturnal cortisol secretory dynamics in healthy older men. Testosterone administration increased early morning serum concentrations of free testosterone by 34%, decreased sex hormone-binding globulin by 20%, and did not alter early morning concentrations of cortisol-binding globulin or cortisol compared with placebo treatment. Testosterone did not significantly alter nocturnal mean and integrated cortisol concentrations, cortisol burst frequency, mass/burst, basal secretion, pulsatile cortisol production rate, pattern regularity, or approximate entropy. We conclude that low-dose testosterone supplementation for 26 weeks does not affect spontaneous nocturnal cortisol secretion in healthy older men.
KW - Aging
KW - Cortisol
KW - Testosterone
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U2 - 10.1093/gerona/glq128
DO - 10.1093/gerona/glq128
M3 - Article
C2 - 20675620
AN - SCOPUS:77958049992
SN - 1079-5006
VL - 65 A
SP - 1185
EP - 1192
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 11
ER -