Effects of superoxide dismutase and allopurinol on the survival of acute island skin flaps

M. J. Im, Paul Manson, G. B. Bulkley, J. E. Hoopes

Research output: Contribution to journalArticle

Abstract

We have demonstrated previously that oxygen-derived free radicals are important mediators of tissue injury following ischemia (total venous occlusion) and reperfusion in small (3 cm x 6 cm) island skin flaps in rats. In this study, we evaluated extension of this concept to regional ischemia in large (8 cm x 8 cm) acute island skin flaps which were constructed in exceed their sole blood supply via unilateral inferior epigastric vessels. Under normal (control) circumstances, a significant portion of the flap would undergo necrosis at the periphery, mimicking the corresponding clinical situation. Blocking the generation of superoxide radicals from xanthine oxidase with a single dose of allopurinol prior to flap elevation significantly improved the area of flap viability from 34 ± 12% to 57 ± 6% (p <0.01) in the random portion of the flap, contralateral to the source of blood supply. Similarly, the detoxification of superoxide radicals with a single dose of superoxide dismutase improved viability from 41 ± 6% to 58 ± 7% (p <0.01). Similar results were obtained when either of these agents were administered 60 min after flap elevation. These findings suggest that oxygen-derived free radicals play an important role in the development of tissue necrosis in the critical transition zone between well-vascularized and devascularized skin.

Original languageEnglish (US)
Pages (from-to)357-359
Number of pages3
JournalAnnals of Surgery
Volume201
Issue number3
StatePublished - 1985

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Surgical Flaps
Allopurinol
Superoxide Dismutase
Superoxides
Skin
Free Radicals
Necrosis
Ischemia
Oxygen
Xanthine Oxidase
Reperfusion
Wounds and Injuries

ASJC Scopus subject areas

  • Surgery

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Effects of superoxide dismutase and allopurinol on the survival of acute island skin flaps. / Im, M. J.; Manson, Paul; Bulkley, G. B.; Hoopes, J. E.

In: Annals of Surgery, Vol. 201, No. 3, 1985, p. 357-359.

Research output: Contribution to journalArticle

Im, M. J. ; Manson, Paul ; Bulkley, G. B. ; Hoopes, J. E. / Effects of superoxide dismutase and allopurinol on the survival of acute island skin flaps. In: Annals of Surgery. 1985 ; Vol. 201, No. 3. pp. 357-359.
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