Effects of substance P on sympathetic preganglionic neurones

Michael P. Gilbey, Kevin E. McKenna, Lawrence P. Schramm

Research output: Contribution to journalArticlepeer-review


Antidromically identified sympathetic preganglionic neurones, located in the second thoracic segment of the rat spinal cord, were tested for their response to iontophoretically applied substance P. Substance P increased the firing rate of both 'spontaneously' active and glutamate-activated neurones. As substance P-like immunoreactivity is present in the intermediolateral cell column of the thoracic spinal cord, it is concluded that substance P may be an excitatory transmitter or modulator involved in mediating excitatory drive to sympathetic preganglionic neurones.

Original languageEnglish (US)
Pages (from-to)157-159
Number of pages3
JournalNeuroscience Letters
Issue number1-2
StatePublished - Oct 31 1983


  • cardiovascular regulation
  • rats
  • substance P
  • sympathetic preganglionic neurones
  • ventral medulla

ASJC Scopus subject areas

  • Neuroscience(all)


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