Abstract
Antidromically identified sympathetic preganglionic neurones, located in the second thoracic segment of the rat spinal cord, were tested for their response to iontophoretically applied substance P. Substance P increased the firing rate of both 'spontaneously' active and glutamate-activated neurones. As substance P-like immunoreactivity is present in the intermediolateral cell column of the thoracic spinal cord, it is concluded that substance P may be an excitatory transmitter or modulator involved in mediating excitatory drive to sympathetic preganglionic neurones.
Original language | English (US) |
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Pages (from-to) | 157-159 |
Number of pages | 3 |
Journal | Neuroscience Letters |
Volume | 41 |
Issue number | 1-2 |
DOIs | |
State | Published - Oct 31 1983 |
Keywords
- cardiovascular regulation
- rats
- substance P
- sympathetic preganglionic neurones
- ventral medulla
ASJC Scopus subject areas
- General Neuroscience