Effects of substance P on sympathetic preganglionic neurones

Michael P. Gilbey, Kevin E. McKenna, Lawrence P. Schramm

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


Antidromically identified sympathetic preganglionic neurones, located in the second thoracic segment of the rat spinal cord, were tested for their response to iontophoretically applied substance P. Substance P increased the firing rate of both 'spontaneously' active and glutamate-activated neurones. As substance P-like immunoreactivity is present in the intermediolateral cell column of the thoracic spinal cord, it is concluded that substance P may be an excitatory transmitter or modulator involved in mediating excitatory drive to sympathetic preganglionic neurones.

Original languageEnglish (US)
Pages (from-to)157-159
Number of pages3
JournalNeuroscience Letters
Issue number1-2
StatePublished - Oct 31 1983


  • cardiovascular regulation
  • rats
  • substance P
  • sympathetic preganglionic neurones
  • ventral medulla

ASJC Scopus subject areas

  • Neuroscience(all)


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