Effects of sublingually given naloxone in opioid-dependent human volunteers

Kenzie L. Preston; George E. Bigelow; Ira A. Liebson

doi:10.1016/0376-8716(90)90136-3

Effects of sublingually given naloxone in opioid-dependent human volunteers

Kenzie L. Preston, George E. Bigelow, Ira A. Liebson

School of Medicine

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

To determine whether sublingual naloxone could precipitate withdrawal in opioid-dependent subjects, naloxone was administered in increasing doses (0-8 mg in four or six sessions conducted over 2 days) to six heroin abusers and three methadone (30 mg/day, p.o.) maintenance patients. Two or three sessions were conducted per day with 2- to 2.5-h intervals between sameday sessions. Naloxone precipitated withdrawal in two of six heroin abusers and in all three methadone subjects. Naloxone is sufficiently absorbed sublingually to precipitate abstinence in dependent subjects, but naloxone doses up to 1-2 mg can be administered sublingually to opioid abusers/addicts without precipitating withdrawal.

Original language	English (US)
Pages (from-to)	27-34
Number of pages	8
Journal	Drug and alcohol dependence
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/0376-8716(90)90136-3
State	Published - Feb 1990

Keywords

human subjects
methadone
naloxone
opioid antagonist
opioid withdrawal/physical dependence
sublingual administration

ASJC Scopus subject areas

Toxicology
Pharmacology
Psychiatry and Mental health
Pharmacology (medical)

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10.1016/0376-8716(90)90136-3

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title = "Effects of sublingually given naloxone in opioid-dependent human volunteers",

abstract = "To determine whether sublingual naloxone could precipitate withdrawal in opioid-dependent subjects, naloxone was administered in increasing doses (0-8 mg in four or six sessions conducted over 2 days) to six heroin abusers and three methadone (30 mg/day, p.o.) maintenance patients. Two or three sessions were conducted per day with 2- to 2.5-h intervals between sameday sessions. Naloxone precipitated withdrawal in two of six heroin abusers and in all three methadone subjects. Naloxone is sufficiently absorbed sublingually to precipitate abstinence in dependent subjects, but naloxone doses up to 1-2 mg can be administered sublingually to opioid abusers/addicts without precipitating withdrawal.",

keywords = "human subjects, methadone, naloxone, opioid antagonist, opioid withdrawal/physical dependence, sublingual administration",

author = "Preston, {Kenzie L.} and Bigelow, {George E.} and Liebson, {Ira A.}",

note = "Funding Information: This study was supported by a grant from Reckitt and Colman Pharmaceutical Division and USPHS Grants DA-00050 and DA-04089 from the National Institute on Drug Abuse.",

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AU - Preston, Kenzie L.

AU - Bigelow, George E.

AU - Liebson, Ira A.

N1 - Funding Information: This study was supported by a grant from Reckitt and Colman Pharmaceutical Division and USPHS Grants DA-00050 and DA-04089 from the National Institute on Drug Abuse.

PY - 1990/2

Y1 - 1990/2

N2 - To determine whether sublingual naloxone could precipitate withdrawal in opioid-dependent subjects, naloxone was administered in increasing doses (0-8 mg in four or six sessions conducted over 2 days) to six heroin abusers and three methadone (30 mg/day, p.o.) maintenance patients. Two or three sessions were conducted per day with 2- to 2.5-h intervals between sameday sessions. Naloxone precipitated withdrawal in two of six heroin abusers and in all three methadone subjects. Naloxone is sufficiently absorbed sublingually to precipitate abstinence in dependent subjects, but naloxone doses up to 1-2 mg can be administered sublingually to opioid abusers/addicts without precipitating withdrawal.

AB - To determine whether sublingual naloxone could precipitate withdrawal in opioid-dependent subjects, naloxone was administered in increasing doses (0-8 mg in four or six sessions conducted over 2 days) to six heroin abusers and three methadone (30 mg/day, p.o.) maintenance patients. Two or three sessions were conducted per day with 2- to 2.5-h intervals between sameday sessions. Naloxone precipitated withdrawal in two of six heroin abusers and in all three methadone subjects. Naloxone is sufficiently absorbed sublingually to precipitate abstinence in dependent subjects, but naloxone doses up to 1-2 mg can be administered sublingually to opioid abusers/addicts without precipitating withdrawal.

KW - human subjects

KW - methadone

KW - naloxone

KW - opioid antagonist

KW - opioid withdrawal/physical dependence

KW - sublingual administration

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ER -

Effects of sublingually given naloxone in opioid-dependent human volunteers

Abstract

Keywords

ASJC Scopus subject areas

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