Effects of subanaesthetic and anaesthetic doses of sevoflurane on regional cerebral blood flow in healthy volunteers. A positron emission tomographic study

Lise Schlünzen, M. S. Vafaee, G. E. Cold, M. Rasmussen, J. F. Nielsen, A. Gjedde

Research output: Contribution to journalArticle

Abstract

Background: We tested the hypothesis that escalating drug concentrations of sevoflurane are associated with a significant decline of cerebral blood flow in regions subserving conscious brain activity, including specifically the thalamus. Methods: Nine healthy human volunteers received three escalating doses using 0.4%, 0.7% and 2.0% end-tidal sevoflurane inhalation. During baseline and each of the three levels of anaesthesia one PET scan was performed after injection of H215O. Cardiovascular and respiratory parameters were monitored and electroencephalography and bispectral index (BIS) were registered. Results: Sevoflurane decreased the BIS values dose-dependently. No significant change in global cerebral blood flow (CBF) was observed. Increased regional CBF (rCBF) in the anterior cingulate (17-21%) and decreased rCBF in the cerebellum (18-35%) were identified at all three levels of sedation compared to baseline. Comparison between adjacent levels sevoflurane initially (0 vs. 0.2 MAC) decreased rCBF significantly in the inferior temporal cortex and the lingual gyrus. At the next level (0.2 MAC vs. 0.4 MAC) rCBF was increased in the middle temporal cortex and in the lingual gyrus, and decreased in the thalamus. At the last level (0.4 MAC vs. 1 MAC) the rCBF was increased in the insula and decreased in the posterior cingulate, the lingual gyrus, precuneus and in the frontal cortex. Conclusion: At sevoflurane concentrations at 0.7% and 2.0% a significant decrease in relative rCBF was detected in the thalamus. Interestingly, some of the most profound changes in rCBF were observed in structures related to pain processing (anterior cingulate and insula).

Original languageEnglish (US)
Pages (from-to)1268-1276
Number of pages9
JournalActa Anaesthesiologica Scandinavica
Volume48
Issue number10
DOIs
StatePublished - Nov 2004
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Regional Blood Flow
Anesthetics
Healthy Volunteers
Occipital Lobe
Electrons
Gyrus Cinguli
Thalamus
Temporal Lobe
Parietal Lobe
Frontal Lobe
Positron-Emission Tomography
Cerebellum
Inhalation
Electroencephalography
Anesthesia
sevoflurane
Pain
Injections
Brain

Keywords

  • Anaesthesia
  • Cerebral blood flow
  • PET
  • Sevoflurane

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Effects of subanaesthetic and anaesthetic doses of sevoflurane on regional cerebral blood flow in healthy volunteers. A positron emission tomographic study. / Schlünzen, Lise; Vafaee, M. S.; Cold, G. E.; Rasmussen, M.; Nielsen, J. F.; Gjedde, A.

In: Acta Anaesthesiologica Scandinavica, Vol. 48, No. 10, 11.2004, p. 1268-1276.

Research output: Contribution to journalArticle

Schlünzen, Lise ; Vafaee, M. S. ; Cold, G. E. ; Rasmussen, M. ; Nielsen, J. F. ; Gjedde, A. / Effects of subanaesthetic and anaesthetic doses of sevoflurane on regional cerebral blood flow in healthy volunteers. A positron emission tomographic study. In: Acta Anaesthesiologica Scandinavica. 2004 ; Vol. 48, No. 10. pp. 1268-1276.
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T1 - Effects of subanaesthetic and anaesthetic doses of sevoflurane on regional cerebral blood flow in healthy volunteers. A positron emission tomographic study

AU - Schlünzen, Lise

AU - Vafaee, M. S.

AU - Cold, G. E.

AU - Rasmussen, M.

AU - Nielsen, J. F.

AU - Gjedde, A.

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