Effects of spatial resolution on image registration

Can Zhao, Aaron Carass, Amod Jog, Jerry Ladd Prince

Research output: Chapter in Book/Report/Conference proceedingConference contribution


This paper presents a theoretical analysis of the effect of spatial resolution on image registration. Based on the assumption of additive Gaussian noise on the images, the mean and variance of the distribution of the sum of squared differences (SSD) were estimated. Using these estimates, we evaluate a distance between the SSD distributions of aligned images and non-aligned images. The experimental results show that by matching the resolutions of the moving and fixed images one can get a better image registration result. The results agree with our theoretical analysis of SSD, but also suggest that it may be valid for mutual information as well.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2016: Image Processing
ISBN (Electronic)9781510600195
StatePublished - 2016
EventMedical Imaging 2016: Image Processing - San Diego, United States
Duration: Mar 1 2016Mar 3 2016


OtherMedical Imaging 2016: Image Processing
CountryUnited States
CitySan Diego


  • Image registration
  • Resolution

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Zhao, C., Carass, A., Jog, A., & Prince, J. L. (2016). Effects of spatial resolution on image registration. In Medical Imaging 2016: Image Processing (Vol. 9784). [97840Y] SPIE. https://doi.org/10.1117/12.2217322