TY - JOUR
T1 - Effects of solvents on the structure of myelin in the sciatic nerve of the frog
AU - Elkes, J.
AU - Finean, J. B.
N1 - Funding Information:
We wish to thank Professor E. K. Rideal, F.R.S., and the Managers of the Royal Institution for facilities provided to us at the Davy Faraday Laboratory of the Royal Institution, London; Professor A.C. Frazer for his encouragementa nd interest in this work; Dr. II. G. Sammons for the lipid estimations; Dr J. Teale for much helpful discussion; Mr H. Smith for valuable technical assistance; and the Medical Research Council and Sir Halley Stewart Trust for financial support.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1953
Y1 - 1953
N2 - 1. 1. The effects of ethyl alcohol, ether, and acetone on the X-ray diffraction patterns of fresh nerve and dried nerve have been studied. 2. 2. Ethyl alcohol and acetone vapours produced rapid changes in the diffraction pattern of fresh nerve. Ether vapour had relatively little effect. The effects of mixtures containing varying proportions of alcohol or acetone in Ringer solution were similar to those of the solvent vapours. Ethyl alcohol, acetone, and ether, all readily affected the spacings below 70 A in the dried nerve pattern. The spacings above 70 Å were much more susceptible to alcohol treatment than to ether and acetone. 3. 3. The results are in keeping with the existence in myelin of a highly-ordered lipid-lipoprotein unit.
AB - 1. 1. The effects of ethyl alcohol, ether, and acetone on the X-ray diffraction patterns of fresh nerve and dried nerve have been studied. 2. 2. Ethyl alcohol and acetone vapours produced rapid changes in the diffraction pattern of fresh nerve. Ether vapour had relatively little effect. The effects of mixtures containing varying proportions of alcohol or acetone in Ringer solution were similar to those of the solvent vapours. Ethyl alcohol, acetone, and ether, all readily affected the spacings below 70 A in the dried nerve pattern. The spacings above 70 Å were much more susceptible to alcohol treatment than to ether and acetone. 3. 3. The results are in keeping with the existence in myelin of a highly-ordered lipid-lipoprotein unit.
UR - http://www.scopus.com/inward/record.url?scp=50449112021&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=50449112021&partnerID=8YFLogxK
U2 - 10.1016/0014-4827(53)90190-6
DO - 10.1016/0014-4827(53)90190-6
M3 - Article
AN - SCOPUS:50449112021
VL - 4
SP - 82
EP - 95
JO - Experimental Cell Research
JF - Experimental Cell Research
SN - 0014-4827
IS - 1
ER -