Effects of sibutramine on gastric emptying, intestinal motility and rectal tone in dogs

Junying Xu, Jiande D.Z. Chen

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The aim of this study was to evaluate the effects of sibutramine on gastric emptying, small-bowel contractions, rectal tone and compliance, and gastrointestinal myoelectrical activity. The study was performed in 14 dogs. It was composed of three separate experiments: gastric emptying of liquids and gastrointestinal slow waves; small-bowel contractions; and rectal tone and rectal compliance. Each experiment included two sessions: a control session and a treatment session with sibutramine (5 mg/kg orally) administrated 2 h before the study. Sibutramine significantly accelerated liquid gastric emptying at 75 and 90 min after the meal but did not alter gastrointestinal slow waves. Gastric emptying at 75 and 90 min was 61.42 ± 7.71 and 66.32 ± 7.67% in the control session, and increased to 71.27 ± 5.14 and 75.93 ± 5.29% in the session with sibutramine (p < 0.05, vs. control). Sibutramine significantly inhibited postprandial small-bowel contractions. Sibutramine did not alter the rectal tone, but significantly increased rectal compliance. Sibutramine accelerates gastric emptying of liquids but inhibits small-bowel contractions. These findings suggest the peripheral mechanisms of sibutramine in reducing food intake and causing weight loss in obesity patients.

Original languageEnglish (US)
Pages (from-to)155-162
Number of pages8
JournalDigestive diseases and sciences
Issue number1
StatePublished - Jan 2008
Externally publishedYes


  • Appetite
  • Food intake
  • Gastric emptying
  • Gastrointestinal motility
  • Small-bowel contraction

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology


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