Effects of running the Boston marathon on plasma concentrations of large neutral amino acids

L. A. Conlay, R. J. Wurtman, I. Lopez G-Coviella, J. K. Blusztajn, C. A. Vacanti, M. Logue, M. During, B. Caballero, T. J. Maher, G. Evoniuk

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma large neutral amino acid concentrations were measured in thirty-seven subjects before and after completing the Boston Marathon. Concentrations of tyrosine, phenylalanine, and methionine increased, as did their "plasma ratios" (i.e., the ratio of each amino acid's concentration to the summed plasma concentrations of the other large neutral amino acids which compete with it for brain uptake). No changes were noted in the plasma concentrations of tryptophan, leucine, isoleucine, nor valine; however, the "plasma ratios" of valine, leucine, and isoleucine all decreased. These changes in plasma amino acid patterns may influence neurotransmitter synthesis.

Original languageEnglish (US)
Pages (from-to)65-71
Number of pages7
JournalJournal of Neural Transmission
Volume76
Issue number1
DOIs
StatePublished - Feb 1 1989
Externally publishedYes

Keywords

  • Running
  • amino acids

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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