Effects of respiratory gases on the frequency and duration of obstructive apneic episodes in a patient with the sleep apnea-hypersomnolence syndrome

Samuel Kuna, Joseph Gillen, Sanford Levine

Research output: Contribution to journalArticle


We studied the effects of hyperoxia and hypercapnia on obstructive apneic episodes (OAE) in a 39-year-old male with the sleep apnea and hypersomnolence syndrome (SAHS). While inspiring room air, our patient spent approximately 50% of his non-REM sleep time in OAE. When the inspired gas was changed to 100% oxygen, the frequency of the OAE decreased slightly, but a statistically significant increase in the duration of each episode was noted. Additionally, a CO2 rebreathe under hyperoxic conditions was carried out during non-REM sleep; no OAE were noted during this rebreathe. Therefore, this latter observation suggests that hypercapnia under hyperoxic conditions may reduce the frequency of OAE in patients with the SAHS.

Original languageEnglish (US)
Pages (from-to)108-113
Number of pages6
Issue number2
StatePublished - Jan 1 1982
Externally publishedYes



  • Hypercapnia
  • Hyperoxia
  • Obstructive apneic episodes
  • Sleep apnea-hypersomnolence syndrome
  • Ventilatory control

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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