Effects of respiratory gases on the frequency and duration of obstructive apneic episodes in a patient with the sleep apnea-hypersomnolence syndrome

Samuel Kuna, Joseph S Gillen, Sanford Levine

Research output: Contribution to journalArticle

Abstract

We studied the effects of hyperoxia and hypercapnia on obstructive apneic episodes (OAE) in a 39-year-old male with the sleep apnea and hypersomnolence syndrome (SAHS). While inspiring room air, our patient spent approximately 50% of his non-REM sleep time in OAE. When the inspired gas was changed to 100% oxygen, the frequency of the OAE decreased slightly, but a statistically significant increase in the duration of each episode was noted. Additionally, a CO2 rebreathe under hyperoxic conditions was carried out during non-REM sleep; no OAE were noted during this rebreathe. Therefore, this latter observation suggests that hypercapnia under hyperoxic conditions may reduce the frequency of OAE in patients with the SAHS.

Original languageEnglish (US)
Pages (from-to)108-113
Number of pages6
JournalRespiration
Volume43
Issue number2
DOIs
StatePublished - 1982
Externally publishedYes

Fingerprint

Disorders of Excessive Somnolence
Hypercapnia
Sleep Apnea Syndromes
Sleep
Gases
Hyperoxia
Air
Observation
Oxygen

Keywords

  • Hypercapnia
  • Hyperoxia
  • Obstructive apneic episodes
  • Sleep apnea-hypersomnolence syndrome
  • Ventilatory control

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology

Cite this

Effects of respiratory gases on the frequency and duration of obstructive apneic episodes in a patient with the sleep apnea-hypersomnolence syndrome. / Kuna, Samuel; Gillen, Joseph S; Levine, Sanford.

In: Respiration, Vol. 43, No. 2, 1982, p. 108-113.

Research output: Contribution to journalArticle

@article{cc18b761a47d4a5d971e2721c5b1d877,
title = "Effects of respiratory gases on the frequency and duration of obstructive apneic episodes in a patient with the sleep apnea-hypersomnolence syndrome",
abstract = "We studied the effects of hyperoxia and hypercapnia on obstructive apneic episodes (OAE) in a 39-year-old male with the sleep apnea and hypersomnolence syndrome (SAHS). While inspiring room air, our patient spent approximately 50{\%} of his non-REM sleep time in OAE. When the inspired gas was changed to 100{\%} oxygen, the frequency of the OAE decreased slightly, but a statistically significant increase in the duration of each episode was noted. Additionally, a CO2 rebreathe under hyperoxic conditions was carried out during non-REM sleep; no OAE were noted during this rebreathe. Therefore, this latter observation suggests that hypercapnia under hyperoxic conditions may reduce the frequency of OAE in patients with the SAHS.",
keywords = "Hypercapnia, Hyperoxia, Obstructive apneic episodes, Sleep apnea-hypersomnolence syndrome, Ventilatory control",
author = "Samuel Kuna and Gillen, {Joseph S} and Sanford Levine",
year = "1982",
doi = "10.1159/000194473",
language = "English (US)",
volume = "43",
pages = "108--113",
journal = "Respiration; international review of thoracic diseases",
issn = "0025-7931",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Effects of respiratory gases on the frequency and duration of obstructive apneic episodes in a patient with the sleep apnea-hypersomnolence syndrome

AU - Kuna, Samuel

AU - Gillen, Joseph S

AU - Levine, Sanford

PY - 1982

Y1 - 1982

N2 - We studied the effects of hyperoxia and hypercapnia on obstructive apneic episodes (OAE) in a 39-year-old male with the sleep apnea and hypersomnolence syndrome (SAHS). While inspiring room air, our patient spent approximately 50% of his non-REM sleep time in OAE. When the inspired gas was changed to 100% oxygen, the frequency of the OAE decreased slightly, but a statistically significant increase in the duration of each episode was noted. Additionally, a CO2 rebreathe under hyperoxic conditions was carried out during non-REM sleep; no OAE were noted during this rebreathe. Therefore, this latter observation suggests that hypercapnia under hyperoxic conditions may reduce the frequency of OAE in patients with the SAHS.

AB - We studied the effects of hyperoxia and hypercapnia on obstructive apneic episodes (OAE) in a 39-year-old male with the sleep apnea and hypersomnolence syndrome (SAHS). While inspiring room air, our patient spent approximately 50% of his non-REM sleep time in OAE. When the inspired gas was changed to 100% oxygen, the frequency of the OAE decreased slightly, but a statistically significant increase in the duration of each episode was noted. Additionally, a CO2 rebreathe under hyperoxic conditions was carried out during non-REM sleep; no OAE were noted during this rebreathe. Therefore, this latter observation suggests that hypercapnia under hyperoxic conditions may reduce the frequency of OAE in patients with the SAHS.

KW - Hypercapnia

KW - Hyperoxia

KW - Obstructive apneic episodes

KW - Sleep apnea-hypersomnolence syndrome

KW - Ventilatory control

UR - http://www.scopus.com/inward/record.url?scp=0019941001&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019941001&partnerID=8YFLogxK

U2 - 10.1159/000194473

DO - 10.1159/000194473

M3 - Article

C2 - 6808621

AN - SCOPUS:0019941001

VL - 43

SP - 108

EP - 113

JO - Respiration; international review of thoracic diseases

JF - Respiration; international review of thoracic diseases

SN - 0025-7931

IS - 2

ER -