Effects of repeated stress on regeneration of serotonergic and noradrenergic axons in the cerebral cortex of adult rats

Ying Liu, Yoshiyuki Ishida, Koh Shinoda, Shoji Nakamura

Research output: Contribution to journalArticlepeer-review

Abstract

We examined whether regeneration of serotonergic (5-HT) and noradrenergic (NA) axons might be affected by stress. Neurotoxins to 5-HT or NA axons were injected into the frontal cortex to cause partial denervation. Mild restraint stress (40 min/day) was started 16 days later and given for 14 consecutive days (30-day stressed group). Non-stressed animals were divided into two groups, animals sacrificed at 14 days (14-day control group) and those sacrificed at 30 days (30-day control group) after the toxin injection. In immunohistochemical study, the denervation area of 5-HT axons but not that of NA axons was significantly smaller in the 30-day control group than in the 14-day control group. However, there was no significant difference between the 14-day control and 30-day stressed groups. These findings suggested that regeneration of 5-HT axons occurred earlier than that of NA axons, and that stress exerted inhibitory influence on regeneration of 5-HT axons.

Original languageEnglish (US)
Pages (from-to)227-230
Number of pages4
JournalNeuroscience Letters
Volume339
Issue number3
DOIs
StatePublished - Mar 27 2003
Externally publishedYes

Keywords

  • Degeneration
  • Denervation area
  • Noradrenaline
  • Regeneration
  • Restraint stress
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)

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