Abstract
We examined whether regeneration of serotonergic (5-HT) and noradrenergic (NA) axons might be affected by stress. Neurotoxins to 5-HT or NA axons were injected into the frontal cortex to cause partial denervation. Mild restraint stress (40 min/day) was started 16 days later and given for 14 consecutive days (30-day stressed group). Non-stressed animals were divided into two groups, animals sacrificed at 14 days (14-day control group) and those sacrificed at 30 days (30-day control group) after the toxin injection. In immunohistochemical study, the denervation area of 5-HT axons but not that of NA axons was significantly smaller in the 30-day control group than in the 14-day control group. However, there was no significant difference between the 14-day control and 30-day stressed groups. These findings suggested that regeneration of 5-HT axons occurred earlier than that of NA axons, and that stress exerted inhibitory influence on regeneration of 5-HT axons.
Original language | English (US) |
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Pages (from-to) | 227-230 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 339 |
Issue number | 3 |
DOIs | |
State | Published - Mar 27 2003 |
Externally published | Yes |
Keywords
- Degeneration
- Denervation area
- Noradrenaline
- Regeneration
- Restraint stress
- Serotonin
ASJC Scopus subject areas
- General Neuroscience