Effects of repeated Ro 15-1788 administration in benzodiazepine-dependent baboons

Richard J. Lamb; Roland R. Griffiths

doi:10.1016/0014-2999(85)90220-1

Effects of repeated Ro 15-1788 administration in benzodiazepine-dependent baboons

Richard J. Lamb, Roland R. Griffiths

School of Medicine

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Administration of the benzodiazepine antagonist, Ro 15-1788, to baboons that were chronically exposed to diazepam or triazolam precipitated withdrawal signs. When Ro 15-1788 was administered repeatedly at one or three day intervals, precipitated withdrawal signs were attenuated. However, these baboons remained tolerant to the sedative effects of the doses of benzodiazepines to which they were continously exposed. While tolerance to agonist effects of drugs and development of physical dependence are often thought to be functionally interrelated phenomena, the present results suggest that these may be separable properties of the benzodiazepines. The present results clearly indicate that certain actions of benzodiazepine agonists and antagonists can be indepently regulated.

Original language	English (US)
Pages (from-to)	257-261
Number of pages	5
Journal	European Journal of Pharmacology
Volume	110
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(85)90220-1
State	Published - Apr 2 1985

Keywords

Benzodiazepines
Diazepam
Physical dependence
Ro 15-1788
Tolerance
Triazolam

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(85)90220-1

Cite this

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title = "Effects of repeated Ro 15-1788 administration in benzodiazepine-dependent baboons",

abstract = "Administration of the benzodiazepine antagonist, Ro 15-1788, to baboons that were chronically exposed to diazepam or triazolam precipitated withdrawal signs. When Ro 15-1788 was administered repeatedly at one or three day intervals, precipitated withdrawal signs were attenuated. However, these baboons remained tolerant to the sedative effects of the doses of benzodiazepines to which they were continously exposed. While tolerance to agonist effects of drugs and development of physical dependence are often thought to be functionally interrelated phenomena, the present results suggest that these may be separable properties of the benzodiazepines. The present results clearly indicate that certain actions of benzodiazepine agonists and antagonists can be indepently regulated.",

keywords = "Benzodiazepines, Diazepam, Physical dependence, Ro 15-1788, Tolerance, Triazolam",

author = "Lamb, {Richard J.} and Griffiths, {Roland R.}",

note = "Funding Information: We would like to thank the Upjohn Company for the gift of triazolam, and Hoffmann-LaRochef or the gifts of diazepam and Ro 15-1788. We would also like to thank Ms. P. Brinkley, Ms. E. Cook, Ms. B. Doty and Ms. D. Spicer for their expert technical assistance, Ms. D. Sabotka for typing the manuscript, Dr. S.E. Lukas for helpful surgical and scientific assistance, and Drs. N.A. Ator, M.J. Kuhar, S.E. Lukas, D.E. McMillan, and J.D. Roache for their critical reading of the manuscript. This research was supported by National Institute on Drug Abuse grant DA 01147 and Contract 271-80-3178. R.J. Lamb is a recipient of a National Institute on Drug Abuse National Research Service Award DA 05237. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

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PY - 1985/4/2

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N2 - Administration of the benzodiazepine antagonist, Ro 15-1788, to baboons that were chronically exposed to diazepam or triazolam precipitated withdrawal signs. When Ro 15-1788 was administered repeatedly at one or three day intervals, precipitated withdrawal signs were attenuated. However, these baboons remained tolerant to the sedative effects of the doses of benzodiazepines to which they were continously exposed. While tolerance to agonist effects of drugs and development of physical dependence are often thought to be functionally interrelated phenomena, the present results suggest that these may be separable properties of the benzodiazepines. The present results clearly indicate that certain actions of benzodiazepine agonists and antagonists can be indepently regulated.

AB - Administration of the benzodiazepine antagonist, Ro 15-1788, to baboons that were chronically exposed to diazepam or triazolam precipitated withdrawal signs. When Ro 15-1788 was administered repeatedly at one or three day intervals, precipitated withdrawal signs were attenuated. However, these baboons remained tolerant to the sedative effects of the doses of benzodiazepines to which they were continously exposed. While tolerance to agonist effects of drugs and development of physical dependence are often thought to be functionally interrelated phenomena, the present results suggest that these may be separable properties of the benzodiazepines. The present results clearly indicate that certain actions of benzodiazepine agonists and antagonists can be indepently regulated.

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Effects of repeated Ro 15-1788 administration in benzodiazepine-dependent baboons

Abstract

Keywords

ASJC Scopus subject areas

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