Effects of reduced sodium intake on hypertension control in older individuals

Results from the trial of nonpharmacologic interventions in the elderly (TONE)

Lawrence Appel, Mark A. Espeland, Linda Easter, Alan C. Wilson, Steven Folmar, Clifton R. Lacy

Research output: Contribution to journalArticle

Abstract

Background: Few trials have evaluated the effects of reduced sodium intake in older individuals, and no trial has examined the effects in relevant subgroups such as African Americans. Patients and Methods: The effects of sodium reduction on blood pressure (BP) and hypertension control were evaluated in 681 patients with hypertension, aged 60 to 80 years, randomly assigned to a reduced sodium intervention or control group. Participants (47% women, 23% African Americans) had systolic BP less than 145 mm Hg and diastolic BP less than 85 mm Hg while taking 1 antihypertensive medication. Three months after the start of intervention, medication was withdrawn. The primary end point was occurrence of an average systolic BP of 150 mm Hg or more, an average diastolic BP of 90 mm Hg or more, the resumption of medication, or a cardiovascular event during follow-up (mean, 27.8 months). Results: Compared with control, mean urinary sodium excretion was 40 mmol/d less in the reduced sodium intervention group (P

Original languageEnglish (US)
Pages (from-to)685-693
Number of pages9
JournalArchives of Internal Medicine
Volume161
Issue number5
StatePublished - Mar 12 2001

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Sodium
Blood Pressure
Hypertension
African Americans
Antihypertensive Agents
Control Groups

ASJC Scopus subject areas

  • Internal Medicine

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Effects of reduced sodium intake on hypertension control in older individuals : Results from the trial of nonpharmacologic interventions in the elderly (TONE). / Appel, Lawrence; Espeland, Mark A.; Easter, Linda; Wilson, Alan C.; Folmar, Steven; Lacy, Clifton R.

In: Archives of Internal Medicine, Vol. 161, No. 5, 12.03.2001, p. 685-693.

Research output: Contribution to journalArticle

Appel, Lawrence ; Espeland, Mark A. ; Easter, Linda ; Wilson, Alan C. ; Folmar, Steven ; Lacy, Clifton R. / Effects of reduced sodium intake on hypertension control in older individuals : Results from the trial of nonpharmacologic interventions in the elderly (TONE). In: Archives of Internal Medicine. 2001 ; Vol. 161, No. 5. pp. 685-693.
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