Effects of red wine consumption on kidney FA composition

Julia Araya, Ramón Rodrigo, Myriam Orellana, Vanessa Garcia-Larsen    

Research output: Contribution to journalArticle

Abstract

We studied the effects of red wine consumption on the FA composition of rat kidney. Four groups of adult male rats were fed a balanced diet for 10 wk. The drinking fluid was water (control), red wine, alcohol-free red wine, or ethanol (12.5%, vol/vol). FA composition, lipid peroxidation, and cytochrome P450 content were determined in the kidney. The antioxidant capacity of plasma was also measured. Ethanol decreased the content of long-chain PUFA, whereas red wine maintained the levels of arachidonic (20:4n-6) and eicosapentaenoic (20:5n-3) acids and alcohol-free red wine significantly increased the levels of 20:4n-6. Lipid peroxidation in the red wine and alcohol-free red wine groups was significantly lower than that of both the control and ethanol groups. The diminished renal lipid peroxidation was associated with an increased antioxidant capacity of plasma. Renal cytochrome P450 was elevated by 50% in the ethanol group and diminished by 20% in the alcohol-free red wine group. These data suggest that moderate red wine consumption could contribute to the preservation of the contents of n-3 and n-6 PUFA, particularly 20:4n-6, in rat kidney. Although ethanol increased the content of cytochrome P450 in the kidney, this effect was eliminated by the nonalcoholic components of red wine.

Original languageEnglish (US)
Pages (from-to)275-279
Number of pages5
JournalLipids
Volume38
Issue number3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

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Wine
Kidney
Chemical analysis
Ethanol
Alcohols
Cytochrome P-450 Enzyme System
Lipid Peroxidation
Rats
Lipids
Antioxidants
Plasmas
Nutrition
Drinking
Diet
Control Groups
Acids
Fluids

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

Cite this

Effects of red wine consumption on kidney FA composition. / Araya, Julia; Rodrigo, Ramón; Orellana, Myriam; Garcia-Larsen    , Vanessa.

In: Lipids, Vol. 38, No. 3, 01.03.2003, p. 275-279.

Research output: Contribution to journalArticle

Araya, Julia ; Rodrigo, Ramón ; Orellana, Myriam ; Garcia-Larsen    , Vanessa. / Effects of red wine consumption on kidney FA composition. In: Lipids. 2003 ; Vol. 38, No. 3. pp. 275-279.
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