Effects of psoralen-derivatized oligonucleoside methylphosphonates on vesicular stomatitis virus (VSV) protein synthesis in vitro and in VSV-infected cell

Joel T. Levis; Joanne M. Kean; Paul S. Miller

doi:10.1080/07328319608002404

Effects of psoralen-derivatized oligonucleoside methylphosphonates on vesicular stomatitis virus (VSV) protein synthesis in vitro and in VSV-infected cell

Joel T. Levis, Joanne M. Kean, Paul S. Miller

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Oligodeoxyribonucleoside methylphosphonates (16-mers) targeted to VSV mRNAs were derivatized with 4′-{[N-(aminoethyl)amino]methyl}-4,5′8-trimethylpsoralen. These oligomers specifically inhibit translation of their targeted mRNAs in vitro following UV irradiation of the oligomer-mRNA complexes. Psoralen-derivatized oligonucleoside methylphosphonates are stable in cells and can inhibit VSV protein synthesis in culture following UV-irradiation of VSV-infected cells.

Original language	English (US)
Pages (from-to)	539-557
Number of pages	19
Journal	Nucleosides and Nucleotides
Volume	15
Issue number	1-3
DOIs	https://doi.org/10.1080/07328319608002404
State	Published - Jan 1 1996

ASJC Scopus subject areas

Biochemistry
Genetics

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abstract = "Oligodeoxyribonucleoside methylphosphonates (16-mers) targeted to VSV mRNAs were derivatized with 4′-{[N-(aminoethyl)amino]methyl}-4,5′8-trimethylpsoralen. These oligomers specifically inhibit translation of their targeted mRNAs in vitro following UV irradiation of the oligomer-mRNA complexes. Psoralen-derivatized oligonucleoside methylphosphonates are stable in cells and can inhibit VSV protein synthesis in culture following UV-irradiation of VSV-infected cells.",

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AU - Kean, Joanne M.

AU - Miller, Paul S.

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