Abstract
Oligodeoxyribonucleoside methylphosphonates (16-mers) targeted to VSV mRNAs were derivatized with 4′-{[N-(aminoethyl)amino]methyl}-4,5′8-trimethylpsoralen. These oligomers specifically inhibit translation of their targeted mRNAs in vitro following UV irradiation of the oligomer-mRNA complexes. Psoralen-derivatized oligonucleoside methylphosphonates are stable in cells and can inhibit VSV protein synthesis in culture following UV-irradiation of VSV-infected cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 539-557 |
| Number of pages | 19 |
| Journal | Nucleosides and Nucleotides |
| Volume | 15 |
| Issue number | 1-3 |
| State | Published - 1996 |
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ASJC Scopus subject areas
- Biochemistry
- Genetics
Cite this
Effects of psoralen-derivatized oligonucleoside methylphosphonates on vesicular stomatitis virus (VSV) protein synthesis in vitro and in VSV-infected cell. / Levis, Joel T.; Kean, Joanne M.; Miller, Paul S.
In: Nucleosides and Nucleotides, Vol. 15, No. 1-3, 1996, p. 539-557.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of psoralen-derivatized oligonucleoside methylphosphonates on vesicular stomatitis virus (VSV) protein synthesis in vitro and in VSV-infected cell
AU - Levis, Joel T.
AU - Kean, Joanne M.
AU - Miller, Paul S.
PY - 1996
Y1 - 1996
N2 - Oligodeoxyribonucleoside methylphosphonates (16-mers) targeted to VSV mRNAs were derivatized with 4′-{[N-(aminoethyl)amino]methyl}-4,5′8-trimethylpsoralen. These oligomers specifically inhibit translation of their targeted mRNAs in vitro following UV irradiation of the oligomer-mRNA complexes. Psoralen-derivatized oligonucleoside methylphosphonates are stable in cells and can inhibit VSV protein synthesis in culture following UV-irradiation of VSV-infected cells.
AB - Oligodeoxyribonucleoside methylphosphonates (16-mers) targeted to VSV mRNAs were derivatized with 4′-{[N-(aminoethyl)amino]methyl}-4,5′8-trimethylpsoralen. These oligomers specifically inhibit translation of their targeted mRNAs in vitro following UV irradiation of the oligomer-mRNA complexes. Psoralen-derivatized oligonucleoside methylphosphonates are stable in cells and can inhibit VSV protein synthesis in culture following UV-irradiation of VSV-infected cells.
UR - http://www.scopus.com/inward/record.url?scp=0029998927&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029998927&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0029998927
VL - 15
SP - 539
EP - 557
JO - Nucleosides and Nucleotides
JF - Nucleosides and Nucleotides
SN - 0732-8311
IS - 1-3
ER -