Effects of psoralen-derivatized oligonucleoside methylphosphonates on vesicular stomatitis virus (VSV) protein synthesis in vitro and in VSV-infected cell

Joel T. Levis, Joanne M. Kean, Paul S. Miller

Research output: Contribution to journalArticlepeer-review

Abstract

Oligodeoxyribonucleoside methylphosphonates (16-mers) targeted to VSV mRNAs were derivatized with 4′-{[N-(aminoethyl)amino]methyl}-4,5′8-trimethylpsoralen. These oligomers specifically inhibit translation of their targeted mRNAs in vitro following UV irradiation of the oligomer-mRNA complexes. Psoralen-derivatized oligonucleoside methylphosphonates are stable in cells and can inhibit VSV protein synthesis in culture following UV-irradiation of VSV-infected cells.

Original languageEnglish (US)
Pages (from-to)539-557
Number of pages19
JournalNucleosides and Nucleotides
Volume15
Issue number1-3
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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