Abstract
Oligodeoxyribonucleoside methylphosphonates (16-mers) targeted to VSV mRNAs were derivatized with 4′-{[N-(aminoethyl)amino]methyl}-4,5′8-trimethylpsoralen. These oligomers specifically inhibit translation of their targeted mRNAs in vitro following UV irradiation of the oligomer-mRNA complexes. Psoralen-derivatized oligonucleoside methylphosphonates are stable in cells and can inhibit VSV protein synthesis in culture following UV-irradiation of VSV-infected cells.
Original language | English (US) |
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Pages (from-to) | 539-557 |
Number of pages | 19 |
Journal | Nucleosides and Nucleotides |
Volume | 15 |
Issue number | 1-3 |
DOIs | |
State | Published - Jan 1 1996 |
ASJC Scopus subject areas
- Biochemistry
- Genetics