Prostaglandin (PG) E1, PGE2 and PGF2α inhibit the release of enzymes from lysosomes of rat pancreas, spleen and kidney cortex in vitro. High concentrations of PGF2α accelerate the release of lysosomal enzymes. Theophylline, papaverine and adenosine 5'-tri-phosphate each potentiate the inhibition by PGE1 and PGF2α, and reduce the acceleration by PGF2α, of lysosomal enzyme release. The dibutyryl analog of cyclic 3', 5'-adenosine monophosphate inhibits, whereas cyclic 3', 5'-guanosine monophosphate accelerates lysosomal enzyme release. The data suggest that inhibition of release of lysosomal enzymes by PGE1 and PGF2α might be mediated by cyclic 3', 5'-adenosine monophosphate.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)