Effects of prostaglandins on release of enzymes from lysosomes of pancreas, spleen and kidney cortex

Louis J. Ignarro, Arnold L. Oronsky, Robert J. Perper

Research output: Contribution to journalArticle

Abstract

Prostaglandin (PG) E1, PGE2 and PGF inhibit the release of enzymes from lysosomes of rat pancreas, spleen and kidney cortex in vitro. High concentrations of PGF accelerate the release of lysosomal enzymes. Theophylline, papaverine and adenosine 5'-tri-phosphate each potentiate the inhibition by PGE1 and PGF, and reduce the acceleration by PGF, of lysosomal enzyme release. The dibutyryl analog of cyclic 3', 5'-adenosine monophosphate inhibits, whereas cyclic 3', 5'-guanosine monophosphate accelerates lysosomal enzyme release. The data suggest that inhibition of release of lysosomal enzymes by PGE1 and PGF might be mediated by cyclic 3', 5'-adenosine monophosphate.

Original languageEnglish (US)
Pages (from-to)193-201
Number of pages9
JournalLife Sciences
Volume12
Issue number5 PART 1
DOIs
StatePublished - Mar 1 1973

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Effects of prostaglandins on release of enzymes from lysosomes of pancreas, spleen and kidney cortex'. Together they form a unique fingerprint.

  • Cite this