Effects of propylthiouracil on D-Galactosamine hepatotoxicity in the rat evidence for a non-thyroidal effect

David S. Cooper, Edward A. Carter, J. David Kieffer, Jack R. Wands

Research output: Contribution to journalArticlepeer-review

Abstract

The cytoprotective effects of propylthiouracil (PTU) were studied in rats treated with the hepatotoxin D-galactosamine (D-GNH2). Five days of PTU pretreatment prior to D-GNH2 caused hypothyroidism and a significant reduction in liver injury as assessed by serum transaminase levels. When PTU was administered as a single dose with d-gnh2, significant decreases in transaminase also occurred at times when thyroid function was unchanged. Furthermore, aminopyrine oxidation showed significant impairment after D-GNH2 and was normalized by one dose of PTU. Further studies were carried out in thyroidectomized rats. PTU caused significant reductions in transaminase levels when given for 5 days pretreatment or as a single dose. Animals receiving pretreatment with PTU plus thyroxine (T4) also had significant decreases in serum transaminase. The antithyroid drug methimazole also had a hepatoprotective effect, while two other potent antithyroid compounds (2-thiouracil and 2-thiobarbituric acid) did not. These data suggest that PTU can protect against liver injury induced by D-GNH2, that the effect is independent of thyroid function, and that this effect is not common to all thiolcontaining antithyroid drugs.

Original languageEnglish (US)
Pages (from-to)3391-3397
Number of pages7
JournalBiochemical Pharmacology
Volume33
Issue number21
DOIs
StatePublished - Nov 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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