Effects of probenecid on the pharmacokinetics of allopurinol riboside

J. B.O. Were, T. A. Shapiro

Research output: Contribution to journalArticlepeer-review

Abstract

Allopurinol riboside is an experimental agent for the treatment of leishmaniasis and American trypanosomiasis. Previous studies showed that after oral administration, unexpectedly low levels of allopurinol riboside in plasma are attributable to incomplete absorption and rapid renal clearance. In this randomized, crossover evaluation in healthy volunteers, probenecid reduces the renal clearance of allopurinol riboside, extends the half-life of allopurinol riboside in plasma, and triples the levels of allopurinol riboside in plasma.

Original languageEnglish (US)
Pages (from-to)1193-1196
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume37
Issue number5
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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