Effects of priming with pancuronium or rocuronium on intubation with rocuronium in children

Soo Kyung Lee, Jung Ryul Kim, Sun Joon Bai, Yang Sik Shin, Yong Taek Nam, Steven P. Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

Rocuronium is a non-depolarizing neuromuscular blocking agent which has a rapid onset and intermediate duration of action. The goat of this study was to compare the neuromuscular blocking actions of rocuronium with and without a priming dose of pancuronium or rocuronium in children. Thirty patients were randomly allocated into 3 groups. Ten patients received a single dose of 0.6 mg/kg rocuronium (Group I). The others received either 0.015 mg/kg pancuronium (Group II) or 0.06 mg/kg rocuronium (Group III) 3 minutes before an intubating dose of 0.54 mg/kg rocuronium was given. Neuromuscular blockade was measured via accelerographic response to single stimulations (1 Hz) of the ulnar nerve until maximal twitch depression was reached followed by train-of-four (TOF) stimuli (2 Hz) at 15 second intervals for the remainder of recovery. Groups were compared with regard to onset time, duration and recovery indices. The onset time and duration of block did not differ significantly between groups. However, the time to recovery in group II (24.5 ± 9.9 min) was significantly prolonged compared to that in group I (12.7 ± 3.1 min) or group III (12.7 ± 3.9 min). We concluded that the use of rocuronium with a preceding dose of either pancuronium or rocuronium provided no advantage for intubation in children.

Original languageEnglish (US)
Pages (from-to)327-330
Number of pages4
JournalYonsei Medical Journal
Volume40
Issue number4
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • Neuromuscular relaxants
  • Onset time
  • Pancuronium
  • Priming principle
  • Rocuronium

ASJC Scopus subject areas

  • Medicine(all)

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