Effects of prednisone, aspirin, and acetaminophen on an in vivo biologic response to interferon in humans

Frank R. Witter, Amina S. Woods, M. Diane Griffin, Craig R. Smith, Paul Nadler, Paul S. Lietman

Research output: Contribution to journalArticle

Abstract

In healthy volunteers receiving a single intramuscular dose of 18 x 106 U interferon alone or after 24 hours of an 8-day course of prednisone (40 mg/day), -aspirin (650 mg every 4 hours); or acetaminophen (650 mg; every 4 hours), the magnitude of the biologic response to interferon was quantified by measuring the time course of the induction of 2′-5′-oligoadenylate synthetase and resistance to vesicular stomatitis virus infection in human peripheral blood mononuclear cells. Prednisone decreased the AUC of 2′-5′-oligoadenylate synthetase activity (p < 0.05), whereas administration of aspirin or acetaminophen did not affect this biologic response. No measurable effect was seen during administration of prednisone, aspirin, or acetaminophen on the duration or intensity of vesicular stomatitis virus yield reduction. The side effects seen with interferon administration at the dose tested were not altered in a clinically meaningful manner by prednisone, aspirin, or acetaminophen.

Original languageEnglish (US)
Pages (from-to)239-243
Number of pages5
JournalClinical pharmacology and therapeutics
Volume44
Issue number2
DOIs
StatePublished - Aug 1988

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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