Effects of positive end expiratory pressure on shunt flow in atelectasis

Suresh Enjeti, John T. O'Neill, Peter Browne Terry, Harold A. Menkes, Richard J. Traystman

Research output: Contribution to journalArticle

Abstract

We studied the effects of positive end expiratory pressure (PEEP) on vascular pressure flow relationships in atelectatic lobes in closed-chest pigs and compared our results to measurements we previously obtained in sublobar atelectasis. Regional hemodynamic responses to lung inflation were significantly different between lobes and sublobar regions. PEEP caused marked increase in the fraction of cardiac output perfusing the atelectatic lobe from 16.5 ± 2.0% (SE) to 32.5 ± 2.0% at similar pulmonary vascular transmural pressures. In contrast, similar levels of PEEP failed to redistribute blood flow to the atelectatic sublobar regions. We propose that distortion of the sublobar region with inflation of the surrounding lung may be responsible for the failure of redistribution of pulmonary blood flow with application of PEEP.

Original languageEnglish (US)
Pages (from-to)243-254
Number of pages12
JournalRespiration Physiology
Volume48
Issue number2
DOIs
StatePublished - 1982

Fingerprint

Pulmonary Atelectasis
Positive-Pressure Respiration
Lung
Economic Inflation
Blood Vessels
Pressure
Cardiac Output
Swine
Thorax
Hemodynamics

Keywords

  • Atelectasis
  • Blood pressure
  • Cardiac output
  • Pig
  • Positive
  • Pulmonary circulation

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Effects of positive end expiratory pressure on shunt flow in atelectasis. / Enjeti, Suresh; O'Neill, John T.; Terry, Peter Browne; Menkes, Harold A.; Traystman, Richard J.

In: Respiration Physiology, Vol. 48, No. 2, 1982, p. 243-254.

Research output: Contribution to journalArticle

Enjeti, Suresh ; O'Neill, John T. ; Terry, Peter Browne ; Menkes, Harold A. ; Traystman, Richard J. / Effects of positive end expiratory pressure on shunt flow in atelectasis. In: Respiration Physiology. 1982 ; Vol. 48, No. 2. pp. 243-254.
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