Effects of portasystemic shunting on visceral and portal blood flow in the dog

C. H. Shatney, John Harmon, N. M. Rich

Research output: Contribution to journalArticle

Abstract

Late effects of portasystemic shunting on visceral and portal vein blood flows were evaluated in mongrel dogs with radioactive microspheres. Sham operation (n = 5) produced no significant long-term changes in visceral blood flow. In contrast, there was a significant increase in small bowel perfusion 3 wk after selective and nonselective portasystemic shunting: end-to-side (n = 7), side-to-side (n = 7), H-graft mesocaval (n = 5), and distal splenorenal (n = 11). Variable increases in pancreatic blood flow were noted in all shunt groups. Portal venous blood flow was significantly elevated in all dogs with total shunts and was substantially increased in animals with H-grafts. Compared with baseline levels, perfusion of organs left in continuity with the portal vein after splenorenal shunting was significantly increased. Blood flow from the small bowel was primarily responsible for the magnitude of the change in portal venous flow. The reduction in hepatic perfusion by portal venous blood appears to trigger these compensatory responses. A humoral mediator best explains the phenomena observed.

Original languageEnglish (US)
Pages (from-to)1170-1176
Number of pages7
JournalGastroenterology
Volume83
Issue number6
StatePublished - 1982
Externally publishedYes

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Dogs
Perfusion
Portal Vein
Transplants
Microspheres
Liver

ASJC Scopus subject areas

  • Gastroenterology

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Effects of portasystemic shunting on visceral and portal blood flow in the dog. / Shatney, C. H.; Harmon, John; Rich, N. M.

In: Gastroenterology, Vol. 83, No. 6, 1982, p. 1170-1176.

Research output: Contribution to journalArticle

Shatney, C. H. ; Harmon, John ; Rich, N. M. / Effects of portasystemic shunting on visceral and portal blood flow in the dog. In: Gastroenterology. 1982 ; Vol. 83, No. 6. pp. 1170-1176.
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