The influence of preexisting lung disease on pulmonary deposition of inhaled particulates was studied in a mouse pneumonia model. Radiolabeled bacteria were introduced by aerosol into mice previously infected with Sendai virus. Equal volumes of consolidated and nonconsolidated areas of the lungs were removed and assayed for the quantity of deposited particles. 90% of the aerosolized bacterial particles were deposited in the nonconsolidated areas, whereas only 10% were found in the consolidated areas of similar volume. Lung disease appears to alter significantly the intrapulmonary deposition of inhaled particles and might influence the hazard of environmental, airborne particulates.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Dec 1 1973|
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine