Effects of physical activity on cardiovascular disease

Haitham M. Ahmed, Michael Blaha, Khurram Nasir, Juan J. Rivera, Roger S Blumenthal

Research output: Contribution to journalArticle

Abstract

Much attention has been directed toward lifestyle modifications as effective means of reducing cardiovascular disease risk. In particular, physical activity has been heavily studied because of its well-known effects on metabolic syndrome, insulin sensitivity, cardiovascular disease risk, and all-cause mortality. However, data regarding the effects of exercise on various stages of the atherosclerosis pathway remain conflicting. The investigators review previously published reports for recent observational and interventional trials investigating the effects of physical activity on markers of (or causal factors for) atherosclerotic burden and vascular disease, including serum lipoproteins, systemic inflammation, thrombosis, coronary artery calcium, and carotid intima-media thickness. In conclusion, the data show a correlation between physical activity and triglyceride reduction, apolipoprotein B reduction, high-density lipoprotein increase, change in low-density lipoprotein particle size, increase in tissue plasminogen activator activity, and decrease in coronary artery calcium. Further research is needed to elucidate the effect of physical activity on inflammatory markers and intima-media thickness.

Original languageEnglish (US)
Pages (from-to)288-295
Number of pages8
JournalThe American Journal of Cardiology
Volume109
Issue number2
DOIs
StatePublished - Jan 15 2012

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Coronary Vessels
Cardiovascular Diseases
Calcium
Carotid Intima-Media Thickness
Apolipoproteins B
Tissue Plasminogen Activator
HDL Lipoproteins
Vascular Diseases
LDL Lipoproteins
Particle Size
Lipoproteins
Insulin Resistance
Life Style
Atherosclerosis
Triglycerides
Thrombosis
Research Personnel
Inflammation
Mortality
Serum

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effects of physical activity on cardiovascular disease. / Ahmed, Haitham M.; Blaha, Michael; Nasir, Khurram; Rivera, Juan J.; Blumenthal, Roger S.

In: The American Journal of Cardiology, Vol. 109, No. 2, 15.01.2012, p. 288-295.

Research output: Contribution to journalArticle

Ahmed, Haitham M. ; Blaha, Michael ; Nasir, Khurram ; Rivera, Juan J. ; Blumenthal, Roger S. / Effects of physical activity on cardiovascular disease. In: The American Journal of Cardiology. 2012 ; Vol. 109, No. 2. pp. 288-295.
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