TY - JOUR
T1 - Effects of phosphotungstic acid and silicotungstic acid on respiration and integrity of rat liver mitochondria
AU - Catterall, William A.
AU - Pedersen, Peter L.
PY - 1970/2/6
Y1 - 1970/2/6
N2 - Phosphotungstic acid and silicotungstic acid, when employed at low concentrations (≤ 0.2 mg/mg protein), were found to markedly inhibit mitochondrial respiration stimulated by either ADP or 2,4-dinitrophenol. At higher concentrations these negative staining agents were found to solubilize significant amounts of mitochondrial protein. The results clearly show that PTA and STA are not biochemically inert and probably have more than a single mitochondrial site of action.
AB - Phosphotungstic acid and silicotungstic acid, when employed at low concentrations (≤ 0.2 mg/mg protein), were found to markedly inhibit mitochondrial respiration stimulated by either ADP or 2,4-dinitrophenol. At higher concentrations these negative staining agents were found to solubilize significant amounts of mitochondrial protein. The results clearly show that PTA and STA are not biochemically inert and probably have more than a single mitochondrial site of action.
UR - http://www.scopus.com/inward/record.url?scp=0014934482&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0014934482&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(70)90727-8
DO - 10.1016/0006-291X(70)90727-8
M3 - Article
C2 - 4192036
AN - SCOPUS:0014934482
SN - 0006-291X
VL - 38
SP - 400
EP - 405
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -