Effects of pharmaceutical medications on male fertility

Paul R. Brezina, Fahd N. Yunus, Yulian Zhao

Research output: Contribution to journalReview articlepeer-review


The number of couples seeking consultation for infertility problems has steadily increased over the past decade, affecting 10%-15% of the sexually active population. Abnormal semen production, a male factor infertility (MFI), is thought to be the cause of up to 50% of all infertilities in developed countries. There are potentially many different causes of male infertility, including hormonal, anatomical, and secondary to exposure to exogenous substances. In many cases of MFI, a definitive cause for abnormalities is never identified. Recently, the research community has given greater attention to identifying causes of MFI ranging from genetic Y chromosome microdeletions to mechanisms of environmental damage on sperm production. Still evolving, is a clear understanding of how many pharmaceutical medications may cause MFI, which is often treatable and reversible. In this review we will outline the data regarding various pharmaceutical medications that have been investigated as possible causes of MFI.

Original languageEnglish (US)
Pages (from-to)3-11
Number of pages9
JournalJournal of Reproduction and Infertility
Issue number1
StatePublished - Jan 1 2012


  • Male infertility
  • Medications
  • Pregnancy
  • Review
  • Sperm

ASJC Scopus subject areas

  • Reproductive Medicine


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