Effects of PGF2α infusion on human cortisol biosynthesis

Anne Colston Wentz; Georgeanna Seegar Jones; Turner Bledsoe; Laura Rocco

doi:10.1016/0090-6980(73)90083-X

Effects of PGF_2α infusion on human cortisol biosynthesis

Anne Colston Wentz, Georgeanna Seegar Jones, Turner Bledsoe, Laura Rocco

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Intravenous administration of prostaglandin F_2α to normal volunteers induced a three-fold increase in urinary cortisol output. Dexamethasone administration significantly inhibited the cortisol response, indicating that prostaglandin does not directly stimulate adrenal cortisol biosynthesis. Prostaglandin infusion appears to increase cortisol biosynthesis through stimulation of pituitary ACTH release.

Original language	English (US)
Pages (from-to)	155-172
Number of pages	18
Journal	Prostaglandins
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/0090-6980(73)90083-X
State	Published - Feb 1973
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Endocrinology

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@article{6ac6c5f952404058847b601a6d48c1ad,

title = "Effects of PGF2α infusion on human cortisol biosynthesis",

abstract = "Intravenous administration of prostaglandin F2α to normal volunteers induced a three-fold increase in urinary cortisol output. Dexamethasone administration significantly inhibited the cortisol response, indicating that prostaglandin does not directly stimulate adrenal cortisol biosynthesis. Prostaglandin infusion appears to increase cortisol biosynthesis through stimulation of pituitary ACTH release.",

author = "Wentz, {Anne Colston} and Jones, {Georgeanna Seegar} and Turner Bledsoe and Laura Rocco",

year = "1973",

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language = "English (US)",

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AU - Wentz, Anne Colston

AU - Jones, Georgeanna Seegar

AU - Bledsoe, Turner

AU - Rocco, Laura

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N2 - Intravenous administration of prostaglandin F2α to normal volunteers induced a three-fold increase in urinary cortisol output. Dexamethasone administration significantly inhibited the cortisol response, indicating that prostaglandin does not directly stimulate adrenal cortisol biosynthesis. Prostaglandin infusion appears to increase cortisol biosynthesis through stimulation of pituitary ACTH release.

AB - Intravenous administration of prostaglandin F2α to normal volunteers induced a three-fold increase in urinary cortisol output. Dexamethasone administration significantly inhibited the cortisol response, indicating that prostaglandin does not directly stimulate adrenal cortisol biosynthesis. Prostaglandin infusion appears to increase cortisol biosynthesis through stimulation of pituitary ACTH release.

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Effects of PGF_2α infusion on human cortisol biosynthesis

Abstract

ASJC Scopus subject areas

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