Effects of PGF infusion on human cortisol biosynthesis

Anne Colston Wentz, Georgeanna Seegar Jones, Turner Bledsoe, Laura Rocco

Research output: Contribution to journalArticlepeer-review


Intravenous administration of prostaglandin F to normal volunteers induced a three-fold increase in urinary cortisol output. Dexamethasone administration significantly inhibited the cortisol response, indicating that prostaglandin does not directly stimulate adrenal cortisol biosynthesis. Prostaglandin infusion appears to increase cortisol biosynthesis through stimulation of pituitary ACTH release.

Original languageEnglish (US)
Pages (from-to)155-172
Number of pages18
Issue number2
StatePublished - Feb 1973

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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