Effects of paeoniflorin, somatostatin and its analogue in sphincter of Oddi in canine with severe acute pancreatitis: A comparative study

Qi Zhu, Lu Xia, Jun Shen, Yaozong Yuan, Jiayu Xu, Qingbo He

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Radix Paeoniae Alba is one of the traditional Chinese medicine used to relax the smooth muscle and paeoniflorin is known as its main active constituent, which may have the potential therapeutic effect on sphincter of Oddi (SO) dysfunction in patients with severe acute pancreatitis (SAP). Aims: To compare the effects of paeoniflorin, somatostatin and its analogue on SO in experimental SAP canine. Methods: Twenty canines were randomly allocated into 4 groups: SAP untreated group, paeoniflorin-, octreotide-, and somatostatin-treated group. The experimental SAP model was constructed by ductal injection of a mixture of 5% sodium taurocholate and autologous bile. The manometric parameters including basal pressure and phasic contraction amplitude (PCA) of SO were measured before and after model construction, 5, 10, 30, 60, 120 and 180 min, respectively after drug administration. Results: In SAP untreated group, the basal pressure of SO increased significantly after model construction (P=0.000 1). After administration of paeoniflorin, octreotide or somatostatin, the basal pressure of SO decreased markedly in SAP canines (P<0.05). Somatostatin was shown to have significant inhibitory effect on PCA of SO (P=0.000 3) in addition but not the paeoniflorin and octreotide (P>0.05). Based on comparison of the difference in decreased SO basal pressure among the three treated groups, the tension decreasing effect of somatostatin was more significant in the initial 5 and 10 min (P<0.05), but no statistical difference was found in the following time points (P>0.05). Conclusions: The abnormal SO pressure is an important factor in the development of SAP and may influence its severity. Paeoniflorin may have potential therapeutic effect on SAP by decreasing the basal pressure of SO. The effect of paeoniflorin is equivalent to a certain degree to that of somatostatin and its analogue.

Original languageEnglish (US)
Pages (from-to)223-226
Number of pages4
JournalChinese Journal of Gastroenterology
Volume10
Issue number4
StatePublished - Dec 1 2005

Keywords

  • Manometry
  • Octreotide
  • PAEONIFLORIN
  • Pancreatitis
  • Somatostatin
  • Sphincter of Oddi

ASJC Scopus subject areas

  • Gastroenterology

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