Effects of ozone and particulate matter on cardiac mechanics: Role of the atrial natriuretic peptide gene

Clarke G. Tankersley, Dimitrios Georgakopoulos, Wan-Yee Tang, Eric Abston, Alexis Bierman, Nicole Sborz

Research output: Contribution to journalArticle

Abstract

A positive association between air pollution exposure and increased human risk of chronic heart disease progression is well established. In the current study, we test two hypotheses: (1) the cardiac compensatory changes in response to air pollution are dependent on its composition and (2) specific cardiac adaptations are regulated by atrial natriuretic peptide (ANP). We address these hypotheses by initially examining the exposure effects of ozone (O3) and/or particulate matter (PM) on cardiac function in C57Bl/6J (B6) mice. Subsequently, the results are compared with cardiac functional changes to the same exposures in Nppa (the precursor gene for ANP) knockout (KO) mice. Separate groups of mice underwent 3 consecutive days of the same exposure sequence for 3h each consisting of the following: (1) 6h of filtered air (FAFA), (2) O3 then FA (O3FA), (3) FA then carbon black (FACB), or (4) O3 then CB. Cardiac function was assessed using a conductance catheter to generate cardiac pressure-volume loops 8-10h following each exposure sequence. As compared with FAFA, each sequence led to a substantial drop (as much as 33%) in stroke volume and cardiac output. However, these losses of cardiac function occurred by different compensatory mechanisms dependent on the pollutant composition. For example, O3FA exposure led to reductions in both end-systolic and end-diastolic left ventricular (LV) volumes, whereas FACB exposure led an increase in end-diastolic LV volume. These same cardiac compensatory changes were largely abolished in Nppa KO mice following O3FA or FACB exposure. These results suggest that cardiac functional changes in response to air pollution exposure are strongly dependent on the pollutant constituents, especially related to O3 and/or PM. Furthermore, ANP regulation appears to be crucial to these cardiac compensatory mechanisms induced by air pollution.

Original languageEnglish (US)
Pages (from-to)95-107
Number of pages13
JournalToxicological Sciences
Volume131
Issue number1
DOIs
StatePublished - Jan 2013

Fingerprint

Particulate Matter
Ozone
Air Pollution
Atrial Natriuretic Factor
Mechanics
Air pollution
Soot
Genes
Stroke Volume
Knockout Mice
Cardiac Volume
Catheters
Chemical analysis
Cardiac Output
Disease Progression
Heart Diseases
Chronic Disease
Air
Association reactions
Pressure

Keywords

  • Air pollution
  • Atrial natriuretic peptide
  • Cardiac structure and function
  • Cardiopulmonary regulation
  • In vivo hemodynamics

ASJC Scopus subject areas

  • Toxicology

Cite this

Effects of ozone and particulate matter on cardiac mechanics : Role of the atrial natriuretic peptide gene. / Tankersley, Clarke G.; Georgakopoulos, Dimitrios; Tang, Wan-Yee; Abston, Eric; Bierman, Alexis; Sborz, Nicole.

In: Toxicological Sciences, Vol. 131, No. 1, 01.2013, p. 95-107.

Research output: Contribution to journalArticle

Tankersley, Clarke G. ; Georgakopoulos, Dimitrios ; Tang, Wan-Yee ; Abston, Eric ; Bierman, Alexis ; Sborz, Nicole. / Effects of ozone and particulate matter on cardiac mechanics : Role of the atrial natriuretic peptide gene. In: Toxicological Sciences. 2013 ; Vol. 131, No. 1. pp. 95-107.
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