Effects of opioid pharmacotherapy on psychomotor and cognitive performance: A review of human laboratory studies of methadone and buprenorphine

Miriam Z. Mintzer

Research output: Contribution to journalReview article

Abstract

Opiod pharmacotheraphy can provide the stability necessary to initiate lifestyle changes, obtain steady employment and function in society. Thus, a critical question is the extent to which pharmacotherapy is associated with impairment in psychomotor and cognitive performance that might affect functioning. In this article, I review human laboratory studies of the effects of the most common opioid pharmacotherapies, methadone and buprenorphine, on psychomotor and cognitive performance (both observational group comparison and experimental drug administration studies) and the effects of withdrawal from opioid pharmacotherapy on performance. I then outline some recommendations for further study in this area.

Original languageEnglish (US)
Pages (from-to)5-24
Number of pages20
JournalHeroin Addiction and Related Clinical Problems
Volume9
Issue number1
StatePublished - Mar 1 2007

Keywords

  • Buprenorphine
  • Cognitive performance
  • Methadone
  • Opioid pharmacotherapy

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health

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