Abstract
Recent work has demonstrated that posttraining systemic opioid antagonist administration facilitates the acquisition of a radial arm maze task in new spatial environments. In this study, we examined the effect of posttraining naloxone and β-endorphin microinjections into the medial septal area on the acquisition of a radial maze task in new spatial environments. The results of these experiments demonstrated that posttraining intraseptal naloxone administration facilitated, whereas posttraining intraseptal β-endorphin administration impaired, the acquisition of criterion performance on a maze task performed in new spatial environments. Further, intraventricular β-endorphin administration did not produce effects that were comparable to those observed following intraseptal β-endorphin administration, which indicates that the septal region is a brain site that is sensitive to the effects of opioids on spatial memory in new environments. Further, posttraining intraseptal β-endorphin administration had no effect on working memory in a familiar spatial environment, whereas pretraining intraseptal β-endorphin administration had no effect on the performance of a previously acquired spatial task.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 643-652 |
| Number of pages | 10 |
| Journal | Behavioral Neuroscience |
| Volume | 102 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 1988 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Behavioral Neuroscience
- Clinical Psychology
Cite this
Effects of Opioid Microinjections Into the Medial Septal Area on Spatial Memory in Rats. / Bostock, Elizabeth; Gallagher, Michela; King, Richard A.
In: Behavioral Neuroscience, Vol. 102, No. 5, 10.1988, p. 643-652.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of Opioid Microinjections Into the Medial Septal Area on Spatial Memory in Rats
AU - Bostock, Elizabeth
AU - Gallagher, Michela
AU - King, Richard A.
PY - 1988/10
Y1 - 1988/10
N2 - Recent work has demonstrated that posttraining systemic opioid antagonist administration facilitates the acquisition of a radial arm maze task in new spatial environments. In this study, we examined the effect of posttraining naloxone and β-endorphin microinjections into the medial septal area on the acquisition of a radial maze task in new spatial environments. The results of these experiments demonstrated that posttraining intraseptal naloxone administration facilitated, whereas posttraining intraseptal β-endorphin administration impaired, the acquisition of criterion performance on a maze task performed in new spatial environments. Further, intraventricular β-endorphin administration did not produce effects that were comparable to those observed following intraseptal β-endorphin administration, which indicates that the septal region is a brain site that is sensitive to the effects of opioids on spatial memory in new environments. Further, posttraining intraseptal β-endorphin administration had no effect on working memory in a familiar spatial environment, whereas pretraining intraseptal β-endorphin administration had no effect on the performance of a previously acquired spatial task.
AB - Recent work has demonstrated that posttraining systemic opioid antagonist administration facilitates the acquisition of a radial arm maze task in new spatial environments. In this study, we examined the effect of posttraining naloxone and β-endorphin microinjections into the medial septal area on the acquisition of a radial maze task in new spatial environments. The results of these experiments demonstrated that posttraining intraseptal naloxone administration facilitated, whereas posttraining intraseptal β-endorphin administration impaired, the acquisition of criterion performance on a maze task performed in new spatial environments. Further, intraventricular β-endorphin administration did not produce effects that were comparable to those observed following intraseptal β-endorphin administration, which indicates that the septal region is a brain site that is sensitive to the effects of opioids on spatial memory in new environments. Further, posttraining intraseptal β-endorphin administration had no effect on working memory in a familiar spatial environment, whereas pretraining intraseptal β-endorphin administration had no effect on the performance of a previously acquired spatial task.
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U2 - 10.1037/0735-7044.102.5.643
DO - 10.1037/0735-7044.102.5.643
M3 - Article
C2 - 3196434
AN - SCOPUS:0023682091
VL - 102
SP - 643
EP - 652
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
SN - 0735-7044
IS - 5
ER -