Effects of nortriptyline on heart rate variability in panic disorder patients: A preliminary study using power spectral analysis of heart rate

V. K. Yeragani, K. Srinivasan, Robert Pohl, Ronald D Berger, Richard Baton, C. Ramesh

Research output: Contribution to journalArticle

Abstract

Previous reports on heart rate variability suggest that, compared to controls, panic disorder patients have a higher relative mid-frequency (MF) (0.07- 0.15 Hz) power in standing posture and that they also have a greater increase in standing MF power after the administration of yohimbine. We studied the effects of nortriptyline, a tricyclic antidepressant, on HR variability measures in 13 panic disorder patients before and after successful treatment. There was a highly significant increase in supine and standing HR (p = 0.00001) while there was a significant decrease of standing absolute and relative MF power (p = 0.009 and 0.0001 respectively). This uncontrolled preliminary study suggests a decrease in sympathetic activity related to nortriptyline treatment in addition to its anticholinergic effects.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalNeuropsychobiology
Volume29
Issue number1
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Nortriptyline
Panic Disorder
Heart Rate
Yohimbine
Tricyclic Antidepressive Agents
Cholinergic Antagonists
Posture
Therapeutics
Power (Psychology)

Keywords

  • Heart rate variability
  • Nortriptyline
  • Panic disorder
  • Spectral analysis
  • Tricyclics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychology(all)

Cite this

Effects of nortriptyline on heart rate variability in panic disorder patients : A preliminary study using power spectral analysis of heart rate. / Yeragani, V. K.; Srinivasan, K.; Pohl, Robert; Berger, Ronald D; Baton, Richard; Ramesh, C.

In: Neuropsychobiology, Vol. 29, No. 1, 1994, p. 1-7.

Research output: Contribution to journalArticle

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