Effects of normal aging and SCN1A risk-gene expression on brain metabolites: Evidence for an association between SCN1A and myo-inositol

Nuran Tunc-Skarka, Sandra Meier, Traute Demirakca, Markus Sack, Wolfgang Weber-Fahr, Wencke Brusniak, Isabella Wolf, Franziska Matthäus, Thomas G. Schulze, Carsten Diener, Gabriele Ende

Research output: Contribution to journalArticlepeer-review

Abstract

Previously reported MRS findings in the aging brain include lower N-acetylaspartate (NAA) and higher myo-inositol (mI), total creatine (Cr) and choline-containing compound (Cho) concentrations. Alterations in the sodium channel voltage gated type I, alpha subunit SCN1A variant rs10930201 have been reported to be associated with several neurological disorders with cognitive deficits. MRS studies in SCN1A-related diseases have reported striking differences in the mI concentrations between patients and controls. In a study on 'healthy aging', we investigated metabolite spectra in a sample of 83 healthy volunteers and determined their age dependence. We also investigated a potential link between SCN1A and mI. We observed a significantly negative association of NAA (p=0.004) and significantly positive associations of mI (p≤0.001), Cr (p≤0.001) and Cho (p=0.034) with age in frontal white matter. The linear association of Cho ends at the age of about 50 years and is followed by an inverted 'U'-shaped curve. Further, mI was higher in C allele carriers of the SCN1A variant rs10930201. Our results corroborated the age-related changes in metabolite concentrations, and found evidence for a link between SCN1A and frontal white matter mI in healthy subjects.

Original languageEnglish (US)
Pages (from-to)228-234
Number of pages7
JournalNMR in Biomedicine
Volume27
Issue number2
DOIs
StatePublished - Feb 2014
Externally publishedYes

Keywords

  • Healthy aging
  • MRS
  • Myo-inositol
  • SCN1A
  • White matter

ASJC Scopus subject areas

  • Spectroscopy
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

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