Effects of negative life events on immune suppression in children and youth infected with human immunodeficiency virus type 1

Lois C. Howland, Steven L. Gortmaker, Lynne M. Mofenson, Cathie Spino, Jane D. Gardner, Heather Gorski, Mary Glenn Fowler, James Oleske

Research output: Contribution to journalArticle

Abstract

Objectives. To evaluate the association of negative stressful life events experienced over 12 months and the risk of moderate to severe immune suppression among children and youth infected with human immunodeficiency virus type 1 (HIV-1). Methods. Longitudinal study of 618 HIV-1-infected children, baseline ages 1 to 20 years (mean age: 6.4 years), who completed 52 weeks of participation in the Pediatric Late Outcomes Study (Pediatric AIDS Clinical Trials Group Protocol 219). Severity of immune suppression was indicated by the Centers for Disease Control and Prevention Pediatric HIV Disease Classification System, based on CD4 percentages. The total number of negative life events - categorized as none, 1, or >1 life event reported as having occurred in the previous 12 months (previous 6 months for children 1 negative life event had an increased incidence of immune suppression (OR: 2.93; 95% CI: 1.34,6.39), controlling for baseline covariates. Conclusions. Results indicate that negative stressful life events increase the risk of children with HIV-1 infection having impaired immune function. Further research is needed to identify potential mechanisms of the relationship between stressful life events and impaired immune function. These mechanisms include psychoneuroendocrinologic response and difficulties in adherence to therapy after exposure of a child to major negative life events.

Original languageEnglish (US)
Pages (from-to)540-546
Number of pages7
JournalPediatrics
Volume106
Issue number3
StatePublished - 2000
Externally publishedYes

Fingerprint

HIV-1
Pediatrics
Implosive Therapy
Virus Diseases
Centers for Disease Control and Prevention (U.S.)
Clinical Protocols
Longitudinal Studies
Acquired Immunodeficiency Syndrome
Outcome Assessment (Health Care)
Clinical Trials
HIV
Incidence
Research

Keywords

  • Life events
  • Pediatric human immunodeficiency virus disease
  • Percentile

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Howland, L. C., Gortmaker, S. L., Mofenson, L. M., Spino, C., Gardner, J. D., Gorski, H., ... Oleske, J. (2000). Effects of negative life events on immune suppression in children and youth infected with human immunodeficiency virus type 1. Pediatrics, 106(3), 540-546.

Effects of negative life events on immune suppression in children and youth infected with human immunodeficiency virus type 1. / Howland, Lois C.; Gortmaker, Steven L.; Mofenson, Lynne M.; Spino, Cathie; Gardner, Jane D.; Gorski, Heather; Fowler, Mary Glenn; Oleske, James.

In: Pediatrics, Vol. 106, No. 3, 2000, p. 540-546.

Research output: Contribution to journalArticle

Howland, LC, Gortmaker, SL, Mofenson, LM, Spino, C, Gardner, JD, Gorski, H, Fowler, MG & Oleske, J 2000, 'Effects of negative life events on immune suppression in children and youth infected with human immunodeficiency virus type 1', Pediatrics, vol. 106, no. 3, pp. 540-546.
Howland LC, Gortmaker SL, Mofenson LM, Spino C, Gardner JD, Gorski H et al. Effects of negative life events on immune suppression in children and youth infected with human immunodeficiency virus type 1. Pediatrics. 2000;106(3):540-546.
Howland, Lois C. ; Gortmaker, Steven L. ; Mofenson, Lynne M. ; Spino, Cathie ; Gardner, Jane D. ; Gorski, Heather ; Fowler, Mary Glenn ; Oleske, James. / Effects of negative life events on immune suppression in children and youth infected with human immunodeficiency virus type 1. In: Pediatrics. 2000 ; Vol. 106, No. 3. pp. 540-546.
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