Effects of naloxone on normals and chronically anxious patients

R. Hoehn-Saric, B. J. Masek

Research output: Contribution to journalArticlepeer-review


A significant number of normal and chronically anxious subjects were able to discriminate subjectively between a session in which they received naloxone and one which they received a placebo. However, affective and physiological measures did not differ significantly between the drug and placebo sessions. The weakness of the response makes it unlikely that a naloxone-responsive endogenous opioid system is substantially involved in the regulation of anxiety. An unexpected finding from the placebo session data was that, despite increased forehead muscle tension and high self-ratings of distress, chronically anxious subjects showed consistently stable sympathetic activity under resting conditions and mild stress, indicating the existence of a subgroup of generalized anxiety patients with low autonomic reactivity.

Original languageEnglish (US)
Pages (from-to)1041-1050
Number of pages10
JournalBiological psychiatry
Issue number11
StatePublished - Dec 1 1981

ASJC Scopus subject areas

  • Biological Psychiatry


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