TY - JOUR
T1 - Effects of multiple monthly doses of ivermectin on adult Onchocerca volvulus
AU - Duke, B. O.L.
AU - Zea-Flores, G.
AU - Castro, J.
AU - Cupp, E. W.
AU - Munoz, B.
PY - 1990
Y1 - 1990
N2 - This paper assesses the effects on adult Onchocerca volvulus of monthly doses of ivermectin (150 μg/kg) given over 4, 8, and 12 months to patients in Guatemala. Nodules were removed 4 months after the last dose; the adult O. volvulus were extracted by collagenase digestion, studied by histological techniques, and compared with worms from untreated patients. Twelve monthly doses killed a proportion of the adult worms (12% of males and 22% of females), leaving the remainder relatively unaffected and the females slowly resuming embryogenesis. After 8 and 12 doses, a number of female worms had resumed embryogenesis in 1 genital tract only, and in 1 female a total degeneration of 1 ovary was seen. Ivermectin also led to a marked drop in the number of male worms in nodules. No serious adverse reactions occurred and the treatment was well accepted.
AB - This paper assesses the effects on adult Onchocerca volvulus of monthly doses of ivermectin (150 μg/kg) given over 4, 8, and 12 months to patients in Guatemala. Nodules were removed 4 months after the last dose; the adult O. volvulus were extracted by collagenase digestion, studied by histological techniques, and compared with worms from untreated patients. Twelve monthly doses killed a proportion of the adult worms (12% of males and 22% of females), leaving the remainder relatively unaffected and the females slowly resuming embryogenesis. After 8 and 12 doses, a number of female worms had resumed embryogenesis in 1 genital tract only, and in 1 female a total degeneration of 1 ovary was seen. Ivermectin also led to a marked drop in the number of male worms in nodules. No serious adverse reactions occurred and the treatment was well accepted.
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U2 - 10.4269/ajtmh.1990.43.657
DO - 10.4269/ajtmh.1990.43.657
M3 - Article
C2 - 2267970
AN - SCOPUS:0025605295
SN - 0002-9637
VL - 43
SP - 657
EP - 664
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 6
ER -