Effects of multiple monthly doses of ivermectin on adult Onchocerca volvulus

B. O.L. Duke, G. Zea-Flores, J. Castro, E. W. Cupp, B. Munoz

Research output: Contribution to journalArticlepeer-review

Abstract

This paper assesses the effects on adult Onchocerca volvulus of monthly doses of ivermectin (150 μg/kg) given over 4, 8, and 12 months to patients in Guatemala. Nodules were removed 4 months after the last dose; the adult O. volvulus were extracted by collagenase digestion, studied by histological techniques, and compared with worms from untreated patients. Twelve monthly doses killed a proportion of the adult worms (12% of males and 22% of females), leaving the remainder relatively unaffected and the females slowly resuming embryogenesis. After 8 and 12 doses, a number of female worms had resumed embryogenesis in 1 genital tract only, and in 1 female a total degeneration of 1 ovary was seen. Ivermectin also led to a marked drop in the number of male worms in nodules. No serious adverse reactions occurred and the treatment was well accepted.

Original languageEnglish (US)
Pages (from-to)657-664
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume43
Issue number6
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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