@article{c436e01c283d4cf795b0f387126cddf8,
title = "Effects of multiple attempts to quit smoking and relapses to smoking on pulmonary function",
abstract = "The effect of intermittent smoking on pulmonary function was assessed among participants in the Lung Health Study, 5887 adult smokers with evidence of early chronic obstructive pulmonary disease (COPD), followed up for 5 years. The mean annual rate of loss in FEV1% of predicted after year 1 was smallest for those who quit at some point during the first year of the study and stayed quit (-0.33%/year, ±0.05%), intermediate for those who smoked intermittently during the study (-0.58%/year, ±0.05%) and greatest for those who continued to smoke throughout the study (-1.18%/year, ±0.03%). Surprisingly, those who made several attempts to quit smoking had less loss of lung function at comparable cumulative doses of cigarettes than those who continued to smoke. Quitting smoking for an interval followed by relapse to smoking appeared to provide a measurable and lasting benefit in comparison to continuous smoking. In this early COPD population, not only quitting smoking but attempts to quit smoking can prevent some loss of lung function. These results provide some encouragement to exsmokers who relapse on their way to complete cessation.",
keywords = "COPD, Pulmonary function, Smoking cessation, Smoking relapse",
author = "Murray, {Robert P.} and Anthonisen, {Nicholas R.} and Connett, {John E.} and Wise, {Robert A.} and Lindgren, {Paula G.} and Greene, {Paul G.} and Nides, {Mitchell A.}",
note = "Funding Information: The principal investigators and senior staff of the clinical and coordinating centers, the NHLBI, and members of the Safety and Data Monitoring Board are as follows: From Case Western Reserve University, Cleveland, OH: M.D. Altose, MD (Principal Investigator); A.F. Connors, MD (Co-Principal Investigator); S. Redline, MD (Co-Principal Investigator); C.D. Deitz, PhD; and R.F. Rakos, PhD. From Henry Ford Hospital, Detroit, MI: W.A. Conway, Jr., MD (Principal Investigator); A. DeHorn, PhD (Co-Principal Investigator); J.C. Ward, MD (former Co-Principal Investigator); C.S. Hoppe-Ryan, CSW; R.L. Jentons, MA; J.A. Reddick, RN; and C. Sawicki, RN, MPH. From Johns Hopkins University School of Medicine, Baltimore, MD: R.A. Wise, MD (Principal Investigator); S. Permutt, MD (Co-Principal Investigator); and C.S. Rand, PhD (Co- Principal Investigator. From the Mayo Clinic, Rochester, MN: P.D. Scanlon, MD (Principal Investigator); L.J. Davis, PhD (Co-Principal Investigator); R.D. Hurt, MD (Co-Principal Investigator); R.D. Miller, MD (Co-Principal Investigator); D.E. Williams MD (CO-Principal Investigator); G.M. Caron; G.G. Lauger, MS; and S.M. Toogood (Pulmonary Function Quality Control Manager). From the Oregon Health Sciences University, Portland, OR: A.S. Buist, MD (Principal Investigator); W.M. Bjornson-Benson, MPH (Co-Principal Investigator); and L.R. Johnson, PhD (LHS Pulmonary Function Coordinator). From the University of Alabama at Birmingham: W.C. Bailey, MD (Principal Investigator); C.M. Brooks, EdD (Co-Principal Investigator); J.J. Dolce, PhD; P.G. Greene, PhD: D.M. Higgins; M.A. Johnson; C.D. Lorish, PhD; and B.A. Martin. From the University of California, Los Angeles, CA: D.P. Tashkin, MD (Principal Investigator); A.H. Coulson (Co-Principal Investigator); H. Gong, MD (former Co-Principal Investigator); P.I. Harber, MD (Co-Principal Investigator); V.C. Li, PhD, MPH (Co-Principal Investigator); M. Roth, MD (Co-Principal Investigator); M.A. Nides, PhD; M.S. Simmons; and I.P. Zuniga. From the University of Manitoba, Winnipeg, Canada: N.R. Anthonisen, MD (Principal Investigator, Steering Committee Chair); J. Manfreda, MD (Co-Principal Investigator); R.P. Murray, PhD (Co-Principal Investigator); S.C. Rempel-Rossum; and J.M. Stoyko. From the University of Minnesota Coordinating Center, Minneapolis, MN: J.E. Connett, PhD (Principal Investigator); M.O. Kjelsberg, PhD (Co-Principal Investigator); M.K. Cowles, MS; D.A. Durkin; P.L. Enright, MD; K.J. Kurnow, MS; W.W. Lee, MS; P.G. Lindgren, MS; S. Mongin, MS; P. O{\textquoteright}Hara, PhD, (LHS Intervention Coordinator); H.T. Voelker; and L. Waller, PhD. From the University of Pittsburgh, Pittsburgh, PA: G.R. Owens, MD (Principal Investigator); R.M. Rogers, MD (Co-Principal Investigator); J.J. Johnston, PhD; F.P. Pope, MSW; and F.M. Vitale, MA. From the University of Utah, Salt Lake City, UT: R.E. Kanner, MD (Principal Investigator); M.A. Rigdon, PhD (Co-Principal Investigator); K.C. Benton; and P.M. Grant. The Salt Lake City Center has been assisted by the Clinical Research Center, Public Health Research Grant M01-RR00064 from the National Center for Research Resources. From the Safety and Data Monitoring Board: M. Becklake, MD; B. Burrows, MD; P. Cleary, PhD; P. Kimbel, MD (Chairperson; deceased October 27, 1990); L. Nett, RN, RRT (former member); J.K. Ockene, PhD; R. Senior, MD (Chairperson); G.L. Snider, MD; W. Spitzer, MD (former member); and O.D. Williams, PhD. From the National Heart, Lung and Blood Institute Staff, Bethesda, MD: S.S. Hurd, PhD (Director, Division of Lung Diseases); J.P. Kiley, PhD (Project Officer); and M.C. Wu, PhD (Div. of Epidemiology & Clinical Applications). From the Mortality and Morbidity Review Board: S.M. Ayres, MD; R.E. Hyatt, MD; and B.A. Mason, MD. Funding Information: This study was supported by contract N01-HR-46002 from the Division of Lung Diseases of the National Heart, Lung, and Blood Institute (NHLBI). Boehringer Ingelheim Pharmaceutical, Marion Merrell Dow, and Merrell Dow Pharmaceuticals (Canada) contributed drugs used by the study. ",
year = "1998",
month = dec,
doi = "10.1016/S0895-4356(98)00120-6",
language = "English (US)",
volume = "51",
pages = "1317--1326",
journal = "Journal of Clinical Epidemiology",
issn = "0895-4356",
publisher = "Elsevier USA",
number = "12",
}