Effects of morphine on circadian rhythms of motor activity and body temperature in pig-tailed macaques

Michael R. Weed, Robert D Hienz

Research output: Contribution to journalArticle

Abstract

Previous studies of the effects of opiates on motor activity and body temperature in nonhuman primates have been limited in scope and typically only conducted with restrained animals. The present study used radio-telemetry devices to continuously measure activity and temperature in unrestrained pig-tailed macaques for 24 h following morphine administration. Two dose-response functions (0.56 to 5.6 mg/kg, i.m.) were determined, one with morphine administered at 9 a.m. and one with morphine administrated at 3 p.m. Under both the 9 a.m. or 3 p.m. administration schedules, body temperature and activity were increased acutely. Activity was also reduced the following morning after morphine administered at either time. In other regards, morphine's effects on both temperature and activity differed between 9 a.m. and 3 p.m. injection, including periods of decreased activity immediately after the acute increases after 9 a.m. but not 3 p.m. administration. Surprisingly, motor activity also increased 9-12 h post-injection following morphine administered at 9 a.m., but not at 3 p.m. These results clearly show an interaction between timing of morphine administration and effects on temperature and activity. These results also underscore the fact that single injections of drugs may have multiple and delayed effects on circadian rhythms in macaques.

Original languageEnglish (US)
Pages (from-to)487-496
Number of pages10
JournalPharmacology Biochemistry and Behavior
Volume84
Issue number3
DOIs
StatePublished - Jul 2006

Fingerprint

Macaca
Circadian Rhythm
Body Temperature
Morphine
Motor Activity
Swine
Temperature
Injections
Opiate Alkaloids
Telemetry
Telemetering
Radio
Primates
Appointments and Schedules
Animals
Equipment and Supplies
Pharmaceutical Preparations

Keywords

  • Body temperature
  • Circadian rhythm
  • Morphine
  • Motor activity
  • Pig-tailed macaque
  • Radio-telemetry

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Effects of morphine on circadian rhythms of motor activity and body temperature in pig-tailed macaques. / Weed, Michael R.; Hienz, Robert D.

In: Pharmacology Biochemistry and Behavior, Vol. 84, No. 3, 07.2006, p. 487-496.

Research output: Contribution to journalArticle

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