Effects of microgravity or simulated launch on testicular function in rats

R. P. Amann, D. R. Deaver, Barry R Zirkin, G. S. Grills, W. J. Sapp, D. N R Veeramachaneni, J. W. Clemens, S. D. Banerjee, J. Folmer, C. M. Gruppi, D. J. Wolgemuth, C. S. Williams

Research output: Contribution to journalArticle

Abstract

Testes from flight rats on COSMOS 2044 and simulated-launch, vivarium, or caudal-elevation control rats (5/group) were analyzed by subjective and quantitative methods. On the basis of observations of fixed tissue, it was evident that some rats had testicular abnormalities unassociated with treatment and probably existing when they were assigned randomly to the four treatment groups. Considering rats without preexisting abnormalities, diameter of seminiferous tubules and numbers of germ cells per tubule cross section were lower (P <0.05) in flight than in simulated-launch or vivarium rats. However, ratios of germ cells to each other or to Sertoli cells and number of homogenization-resistant spermatids did not differ from values for simulated-launch or vivarium controls. Expression of testis-specific gene products was not greatly altered by flight. Furthermore, there was no evidence for production of stress-inducible transcripts of the hsp70 or hsp90 genes. Concentration of receptors for rat luteinizing hormone in testicular tissue and surface density of smooth endoplasmic reticulum in Leydig cells were similar in flight and simulated-launch rats. However, concentrations of testosterone in testicular tissue or peripheral blood plasma were reduced (P <0.05) in flight rats to 2 wk might result in additional changes. Sequelae of reduced androgen production associated with microgravity on turnover of muscle and bone should be considered.

Original languageEnglish (US)
JournalJournal of Applied Physiology
Volume73
Issue number2 SUPPL.
StatePublished - 1992
Externally publishedYes

Fingerprint

Weightlessness
Germ Cells
Testis
LH Receptors
Smooth Endoplasmic Reticulum
Seminiferous Tubules
Spermatids
Leydig Cells
Sertoli Cells
Bone Remodeling
Androgens
Genes
Testosterone
Cell Count
Muscles

Keywords

  • cellular-stress genes
  • intratesticular testosterone
  • Leydig cells
  • spermatogenesis
  • testis

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Amann, R. P., Deaver, D. R., Zirkin, B. R., Grills, G. S., Sapp, W. J., Veeramachaneni, D. N. R., ... Williams, C. S. (1992). Effects of microgravity or simulated launch on testicular function in rats. Journal of Applied Physiology, 73(2 SUPPL.).

Effects of microgravity or simulated launch on testicular function in rats. / Amann, R. P.; Deaver, D. R.; Zirkin, Barry R; Grills, G. S.; Sapp, W. J.; Veeramachaneni, D. N R; Clemens, J. W.; Banerjee, S. D.; Folmer, J.; Gruppi, C. M.; Wolgemuth, D. J.; Williams, C. S.

In: Journal of Applied Physiology, Vol. 73, No. 2 SUPPL., 1992.

Research output: Contribution to journalArticle

Amann, RP, Deaver, DR, Zirkin, BR, Grills, GS, Sapp, WJ, Veeramachaneni, DNR, Clemens, JW, Banerjee, SD, Folmer, J, Gruppi, CM, Wolgemuth, DJ & Williams, CS 1992, 'Effects of microgravity or simulated launch on testicular function in rats', Journal of Applied Physiology, vol. 73, no. 2 SUPPL..
Amann RP, Deaver DR, Zirkin BR, Grills GS, Sapp WJ, Veeramachaneni DNR et al. Effects of microgravity or simulated launch on testicular function in rats. Journal of Applied Physiology. 1992;73(2 SUPPL.).
Amann, R. P. ; Deaver, D. R. ; Zirkin, Barry R ; Grills, G. S. ; Sapp, W. J. ; Veeramachaneni, D. N R ; Clemens, J. W. ; Banerjee, S. D. ; Folmer, J. ; Gruppi, C. M. ; Wolgemuth, D. J. ; Williams, C. S. / Effects of microgravity or simulated launch on testicular function in rats. In: Journal of Applied Physiology. 1992 ; Vol. 73, No. 2 SUPPL.
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