Effects of methotrexate on group a beta hemolytic streptococci and streptococcal infection

Dean Metcalfe, Walter T. Hughes

Research output: Contribution to journalArticle

Abstract

The incidence of Group A beta hemolytic streptococci and streptococcal infections was lower in children with leukemia than those with no malignancy. Cancer chemotherapy agents were suspected of having some effect on the microbial flora, and methotrexate was investigated. In vitro, methotrexate (MTX) was found to inhibit Group A beta hemolytic streptococci in concentrations of 7.8 μg/ml and less, whereas P. aeruginosa, E. coli, S. aureus, S. marcescens, C. albicans, and Klebsiella‐Enterobacter sp. were resistant to 250 μg/ml. In mice, early death from streptococcal infection was prevented with one injection of MTX, whereas comparable dosage in milligrams of penicillin G failed to protect the animals. These findings indicate that MTX therapy likely influences the incidence of Group A beta hemolytic streptococci and the occurrence of streptococcal infections.

Original languageEnglish (US)
Pages (from-to)588-593
Number of pages6
JournalCancer
Volume30
Issue number2
DOIs
StatePublished - Aug 1972

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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