Effects of medical male circumcision (MC) on plasma HIV viral load in HIV+ HAART naïve men; Rakai, Uganda

Godfrey Kigozi, Richard Musoke, Nehemiah Kighoma, Stephen Watya, David Serwadda, Fred Nalugoda, Noah Kiwanuka, Fred Wabwire-Mangen, Aaron A Tobian, Fredrick Makumbi, Ronald Moses Galiwango, Nelson Sewankambo, James Nkale, Grace Kigozi Nalwoga, Margaret Anyokorit, Tom Lutalo, Ronald H Gray, Maria J Wawer

Research output: Contribution to journalArticle

Abstract

Background: Medical male circumcision (MC) of HIV-infected men may increase plasma HIV viral load and place female partners at risk of infection. We assessed the effect of MC on plasma HIV viral load in HIV-infected men in Rakai, Uganda.

Methods: 195 consenting HIV-positive, HAART naýve men aged 12 and above provided blood for plasma HIV viral load testing before surgery and weekly for six weeks and at 2 and 3 months post surgery. Data were also collected on baseline social demographic characteristics and CD4 counts. Change in log10 plasma viral load between baseline and follow-up visits was estimated using paired t tests and multivariate generalized estimating equation (GEE).

Results: Of the 195 men, 129 had a CD4 count≥350 and 66 had CD4 3. Men with CD4 counts 10 plasma viral load than those with CD4 counts ≥350 cells/mm3 (4.715 vs 4.217 cps/mL, respectively, p=0.0005). Compared to baseline, there was no statistically significant increase in post-MC HIV plasma viral loads irrespective of CD4. Multivariate analysis showed that higher baseline log10plasma viral load was significantly associated with reduction in mean log10 plasma viral load following MC (coef. =-0.134, p

Conclusion: We observed no increase in plasma HIV viral load following MC in HIV-infected, HAART naýve men.e.

Original languageEnglish (US)
Article numbere110382
JournalPLoS One
Volume9
Issue number11
DOIs
StatePublished - Sep 18 2014

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Male Circumcision
Uganda
Highly Active Antiretroviral Therapy
viral load
Viral Load
HIV
Plasmas
CD4 Lymphocyte Count
Surgery
surgery
Load testing
sociodemographic characteristics
blood plasma
multivariate analysis
Blood
Multivariate Analysis
Demography

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Effects of medical male circumcision (MC) on plasma HIV viral load in HIV+ HAART naïve men; Rakai, Uganda. / Kigozi, Godfrey; Musoke, Richard; Kighoma, Nehemiah; Watya, Stephen; Serwadda, David; Nalugoda, Fred; Kiwanuka, Noah; Wabwire-Mangen, Fred; Tobian, Aaron A; Makumbi, Fredrick; Galiwango, Ronald Moses; Sewankambo, Nelson; Nkale, James; Nalwoga, Grace Kigozi; Anyokorit, Margaret; Lutalo, Tom; Gray, Ronald H; Wawer, Maria J.

In: PLoS One, Vol. 9, No. 11, e110382, 18.09.2014.

Research output: Contribution to journalArticle

Kigozi, G, Musoke, R, Kighoma, N, Watya, S, Serwadda, D, Nalugoda, F, Kiwanuka, N, Wabwire-Mangen, F, Tobian, AA, Makumbi, F, Galiwango, RM, Sewankambo, N, Nkale, J, Nalwoga, GK, Anyokorit, M, Lutalo, T, Gray, RH & Wawer, MJ 2014, 'Effects of medical male circumcision (MC) on plasma HIV viral load in HIV+ HAART naïve men; Rakai, Uganda', PLoS One, vol. 9, no. 11, e110382. https://doi.org/10.1371/journal.pone.0110382
Kigozi, Godfrey ; Musoke, Richard ; Kighoma, Nehemiah ; Watya, Stephen ; Serwadda, David ; Nalugoda, Fred ; Kiwanuka, Noah ; Wabwire-Mangen, Fred ; Tobian, Aaron A ; Makumbi, Fredrick ; Galiwango, Ronald Moses ; Sewankambo, Nelson ; Nkale, James ; Nalwoga, Grace Kigozi ; Anyokorit, Margaret ; Lutalo, Tom ; Gray, Ronald H ; Wawer, Maria J. / Effects of medical male circumcision (MC) on plasma HIV viral load in HIV+ HAART naïve men; Rakai, Uganda. In: PLoS One. 2014 ; Vol. 9, No. 11.
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AU - Watya, Stephen

AU - Serwadda, David

AU - Nalugoda, Fred

AU - Kiwanuka, Noah

AU - Wabwire-Mangen, Fred

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AU - Galiwango, Ronald Moses

AU - Sewankambo, Nelson

AU - Nkale, James

AU - Nalwoga, Grace Kigozi

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