TY - JOUR
T1 - Effects of medical male circumcision (MC) on plasma HIV viral load in HIV+ HAART naïve men; Rakai, Uganda
AU - Kigozi, Godfrey
AU - Musoke, Richard
AU - Kighoma, Nehemiah
AU - Watya, Stephen
AU - Serwadda, David
AU - Nalugoda, Fred
AU - Kiwanuka, Noah
AU - Wabwire-Mangen, Fred
AU - Tobian, Aaron
AU - Makumbi, Fredrick
AU - Galiwango, Ronald Moses
AU - Sewankambo, Nelson
AU - Nkale, James
AU - Nalwoga, Grace Kigozi
AU - Anyokorit, Margaret
AU - Lutalo, Tom
AU - Gray, Ronald Henry
AU - Wawer, Maria Joan
N1 - Publisher Copyright:
© 2014 Kigozi et al.
PY - 2014/9/18
Y1 - 2014/9/18
N2 - Background: Medical male circumcision (MC) of HIV-infected men may increase plasma HIV viral load and place female partners at risk of infection. We assessed the effect of MC on plasma HIV viral load in HIV-infected men in Rakai, Uganda.Methods: 195 consenting HIV-positive, HAART naýve men aged 12 and above provided blood for plasma HIV viral load testing before surgery and weekly for six weeks and at 2 and 3 months post surgery. Data were also collected on baseline social demographic characteristics and CD4 counts. Change in log10 plasma viral load between baseline and follow-up visits was estimated using paired t tests and multivariate generalized estimating equation (GEE).Results: Of the 195 men, 129 had a CD4 count≥350 and 66 had CD4 <350 cells/ mm3. Men with CD4 counts <350 had higher baseline mean log10 plasma viral load than those with CD4 counts ≥350 cells/mm3 (4.715 vs 4.217 cps/mL, respectively, p=0.0005). Compared to baseline, there was no statistically significant increase in post-MC HIV plasma viral loads irrespective of CD4. Multivariate analysis showed that higher baseline log10plasma viral load was significantly associated with reduction in mean log10 plasma viral load following MC (coef. =-0.134, p <0.001).Conclusion: We observed no increase in plasma HIV viral load following MC in HIV-infected, HAART naýve men.e.
AB - Background: Medical male circumcision (MC) of HIV-infected men may increase plasma HIV viral load and place female partners at risk of infection. We assessed the effect of MC on plasma HIV viral load in HIV-infected men in Rakai, Uganda.Methods: 195 consenting HIV-positive, HAART naýve men aged 12 and above provided blood for plasma HIV viral load testing before surgery and weekly for six weeks and at 2 and 3 months post surgery. Data were also collected on baseline social demographic characteristics and CD4 counts. Change in log10 plasma viral load between baseline and follow-up visits was estimated using paired t tests and multivariate generalized estimating equation (GEE).Results: Of the 195 men, 129 had a CD4 count≥350 and 66 had CD4 <350 cells/ mm3. Men with CD4 counts <350 had higher baseline mean log10 plasma viral load than those with CD4 counts ≥350 cells/mm3 (4.715 vs 4.217 cps/mL, respectively, p=0.0005). Compared to baseline, there was no statistically significant increase in post-MC HIV plasma viral loads irrespective of CD4. Multivariate analysis showed that higher baseline log10plasma viral load was significantly associated with reduction in mean log10 plasma viral load following MC (coef. =-0.134, p <0.001).Conclusion: We observed no increase in plasma HIV viral load following MC in HIV-infected, HAART naýve men.e.
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U2 - 10.1371/journal.pone.0110382
DO - 10.1371/journal.pone.0110382
M3 - Article
C2 - 25415874
AN - SCOPUS:84913573542
SN - 1932-6203
VL - 9
JO - PloS one
JF - PloS one
IS - 11
M1 - e110382
ER -