Effects of marijuana smoking on subjective ratings and tobacco smoking

R. Nemeth-Coslett, Jack E. Henningfield, Mary K. O'Keeffe, Roland R Griffiths

Research output: Contribution to journalArticle

Abstract

Multiple measures of tobacco cigarette smoking and subjective and physiological effect were collected during 90 minute test sessions in volunteer cigarette smokers who also had histories of recreational marijuana use. Before sessions, subjects smoked one marijuana cigarette (placebo or 1.29%, 2.84%, 4.00%) using a standardized puffing procedure. Each dose and placebo was given four times to each subject in a randomized block sequence. Marijuana smoking produced dose-related increases in heart rate, ratings of dose strength and drug liking. However, marijuana produced no significant alterations in tobacco cigarette smoking. Puff duration within each marijuana cigarette varied in a fashion similar to that observed in previous studies of tobacco cigarette smoking: puff duration progressively decreased as the cigarette was smoked. This effect is probably due to progressive decreases in resistance to draw as the cigarette is smoked. Expired air carbon monoxide (CO) levels following marijuana smoking were inversely related to marijuana dose, suggesting the occurrence of some compensatory changes in marijuana smoking in response to dose manipulations. It is concluded that, although marijuana produces dose-related effects on physiological and subjective effects and on marijuana smoking behavior, marijuana differs from a variety of other psychoactive drugs previously studied in this paradigm in that no reliable changes in tobacco smoking were produced.

Original languageEnglish (US)
Pages (from-to)659-665
Number of pages7
JournalPharmacology Biochemistry and Behavior
Volume25
Issue number3
DOIs
StatePublished - 1986

Fingerprint

Marijuana Smoking
Tobacco
Cannabis
Smoking
Tobacco Products
Placebos
Psychotropic Drugs
Carbon Monoxide
Volunteers
Heart Rate
Air

Keywords

  • Cigarettes
  • Humans
  • Marijuana
  • Nicotine
  • Self-administration
  • Smoking
  • Tobacco

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Effects of marijuana smoking on subjective ratings and tobacco smoking. / Nemeth-Coslett, R.; Henningfield, Jack E.; O'Keeffe, Mary K.; Griffiths, Roland R.

In: Pharmacology Biochemistry and Behavior, Vol. 25, No. 3, 1986, p. 659-665.

Research output: Contribution to journalArticle

Nemeth-Coslett, R. ; Henningfield, Jack E. ; O'Keeffe, Mary K. ; Griffiths, Roland R. / Effects of marijuana smoking on subjective ratings and tobacco smoking. In: Pharmacology Biochemistry and Behavior. 1986 ; Vol. 25, No. 3. pp. 659-665.
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